Internal Thread Cryogenic Vials with Leak-Proof O-Ring Seal
Internally threaded cryogenic vials have screw threads inside the cap neck with a silicone O-ring that compresses against the vial rim to create a positive leak-proof seal rated to 90 kPa. The recessed thread design eliminates exposed external grooves during cap removal, reducing contamination risk to the sealing surface in biosafety cabinets and clean workflows. Available in 1.0 mL, 1.5 mL, 2.0 mL, 3.0 mL, and 5.0 mL, polypropylene, rated from −196°C to +121°C. All are gamma-sterilized and certified RNase-free, DNase-free, and non-pyrogenic. MBP carries Globe Scientific RingSeal vials and ships to labs across the US, Canada, and internationally.
Need help selecting the right internally threaded cryogenic vials for your laboratory? — Contact our team at customerservice@mbpinc.net for product recommendations, bulk pricing, and purchasing assistance.
Internally Threaded Cryogenic Vials
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What Are Internally Threaded Cryogenic Vials?
Internally threaded cryogenic vials feature screw threads located inside the vial neck, allowing the cap to sit within the vial opening rather than wrapping around the exterior. A silicone O-ring in the cap compresses against the vial rim when tightened, creating a secure, leak-resistant seal that remains stable at ultra-low temperatures down to −196°C.
Because the external surface of the vial neck remains smooth, internally threaded designs help reduce contamination risk and improve handling in biosafety cabinets and clean laboratory environments. They are commonly used for long-term storage of biological samples, including cell lines, serum aliquots, and microbial stocks.
What you'll discover:
- 2D barcoded internally threaded cryogenic vials for digital sample tracking
- SBS-format cryogenic vials designed for automated high-throughput systems
- Multi-barcoded vials with side and bottom identifiers for inventory management
- Non-barcoded internally threaded vials for routine laboratory storage
- Side-barcoded cryogenic vials for rapid scanning workflows
- Internally threaded vials available in 0.5–5.0 mL volume formats
- Racked and bulk-pack cryogenic storage configurations
- Leak-resistant vials with integrated silicone sealing systems
How to Choose Internally Threaded Cryogenic Vials
Volume selection
The 2.0 mL format is the most widely used for cell banking, serum aliquots, and general biostorage due to its balance between capacity and rack compatibility. Smaller volumes are used for high-density storage, while larger formats support tissue samples and high-volume biological materials.
O-ring material
Silicone O-rings are preferred because they maintain elasticity and sealing performance across cryogenic and autoclave temperature ranges. This ensures consistent leak protection during freezing and thawing cycles.
Self-standing vs round-bottom
Self-standing vials feature a stable base for bench handling without racks, improving workflow efficiency during labeling and aliquoting. Round-bottom vials require racks but are compatible with a wider range of storage systems.
Autoclavability
Most polypropylene vials with silicone O-rings are autoclavable at 121°C, but material compatibility should always be confirmed before sterilization to avoid deformation or seal failure.
Specifications Context
Internally threaded cryogenic vials are typically manufactured from high-grade polypropylene and are designed for storage temperatures down to −196°C in liquid nitrogen vapor or phase. Many are certified RNase-free, DNase-free, non-pyrogenic, and endotoxin-free to support molecular biology and clinical applications.
They are compatible with standard cryobox formats and are widely used in biobanking, GMP storage, and long-term specimen preservation workflows where sample integrity and traceability are essential.
Internally threaded cryogenic vials remain a core standard for secure biological storage across research and clinical laboratories. Contact the MBP team for pricing and availability.
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