MagBio Genomics

Mag Beads

<h2>What are Magnetic Bead Total RNA Extraction Kits?</h2>
&nbsp;
Magnetic bead total RNA extraction kits isolate total RNA by adsorbing nucleic acids onto paramagnetic silica-coated beads in a high-chaotropic-salt lysis buffer, then using a magnetic field to capture and wash beads without centrifugation. Unlike standard spin-column kits, the bead format removes centrifuge dependency, enabling scalable manual processing in 96-well plates or full automation on liquid-handling robots.&nbsp;Choose a magnetic bead format when your lab processes more than 48 samples per day or when a Tecan, Hamilton, or Beckman Biomek platform is available.
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<h2 dir="ltr">What you will find:</h2>
&nbsp;
<ul>
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Magbio HighPrep Kits for liquid biopsy collection systems and non-invasive swabbing using rapid magnetic bead isolation&nbsp;
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Zymo-Seq RiboFree&trade; Kits to eliminate ribosomal RNA carryover during library synthesis
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Direct-zol-96 MagBead RNA Modules facilitate complete avoidance of manual phase-separation steps while enabling automated transcript extraction directly from TRIzol&reg; lysates&nbsp;
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Magbio HighPrep Total RNA Plus Kit extracts pure, inhibitor-free RNA from complex samples with maximum binding capacity&nbsp;
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Quick-RNA MagBead Packs deliver high-integrity total transcripts without dependence on centrifuge spins or vacuum manifold.
</li>
</ul>
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<h2>How to Choose a Magnetic Bead Total RNA Extraction Kit</h2>
&nbsp;
Automation Compatibility
Confirm that the kit supplier provides automation scripts for your specific platform. The Zymo Research Quick-DNA/RNA Viral MagBead kit and Thermo Fisher MagMAX-96 both offer downloadable instrument scripts for Tecan and Hamilton systems. Generic magnetic bead kits without published automation protocols require in-house script development, adding significant setup time.
Small RNA Retention
Bead kits that bind RNA &gt;=17 nt co-purify microRNAs alongside mRNA and rRNA from the same input. Kits specifying &gt;=200 nt retention exclude small RNAs and are not appropriate for miRNA expression panels. Check the size cutoff stated in the kit datasheet before selecting for non-coding RNA work.
Input Sample Type
Magnetic bead kits for total RNA support cell pellets, tissue homogenates, blood, bacteria, yeast, and fungi. For cell-free matrices (plasma, serum, nasal wash), switch to a viral-RNA or liquid-biopsy magnetic bead kit with included carrier RNA to maximize recovery from low-input, cell-free samples.
Elution Volume and Concentration
Standard magnetic bead kits elute into 50-100 ul; some protocols allow concentration into 20-50 ul, increasing RNA concentration for sensitive downstream applications. If downstream libraries require &gt;=200 ng/ul input, reduce elution volume accordingly and verify the kit supports this protocol variant.
gDNA Removal
Confirm whether the kit includes on-bead DNase I or requires a separate gDNA digestion step. For RT-qPCR and RNA-seq, omitting DNase treatment introduces a genomic DNA signal that inflates expression measurements.
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<h2>Specifications Context</h2>
&nbsp;
RNA purity targets from magnetic bead extractions match spin-column benchmarks: A260/A280 &gt;= 1.8 and A260/A230 &gt;= 1.5. RNA integrity number (RIN) &gt;= 7 is recommended for RNA-seq library preparation; magnetic bead kits produce RIN values in the 8-10 range for fresh samples when lysis is performed immediately on ice. Bead-based workflows are cited in published automation protocols from genomics core facilities and are increasingly specified by NIH-funded projects requiring standardized sample processing across multi-site studies.
<section class="mbp-contact-cta"></section>
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<a href="https://mbpinc.net/contact-us">Contact the expert team </a>at MBP Inc. to get automation-compatible mag bead selections today.

HighPrep™ Total RNA Plus Kit - Protocol

MSDS

DataSheet

Magbio HighPrep Total RNA Plus Kit

HighPrep Total RNA Plus Kit by MagBio Genomics is a magnetic bead-based total RNA extraction kit for swab lysates, tissue (~30 mg), whole blood (200 µL), and cultured cells (1×10⁶) — 7-step protocol with included DNase treatment, OD260/280 purity 1.9–2.0, ≥30 µL elution, KingFisher Flex compatible. Available in 50-prep, 100-prep, and 400-prep formats.

Features

Main functions

Starting material (Sample matrix)

Sample amount (Input)

Downstream application

Process method

Instrument

Purification method

RNA Purity

Elution Volume

Manufacturer

HighPrep Total RNA Plus Kit (5 preps)

HighPrepTotal RNA Plus Kit (50 preps)

HighPrep Total RNA Plus Kit (100 preps)

HighPrep Total RNA Plus Kit (400 preps)

<h2>What are Magnetic Bead Viral DNA/RNA Co-Extraction Kits?</h2>
&nbsp;
Magnetic bead viral DNA/RNA co-extraction kits purify both viral DNA and RNA from plasma, serum, urine, nasopharyngeal swabs, saliva, blood, cellular suspensions, biopsies, fecal samples, and cell culture media stored in DNA/RNA Shield using paramagnetic silica-coated beads that bind nucleic acids from &gt;50 nt to &gt;200 kb during a single chaotropic lysis step, with magnetic separation during successive wash steps removing inhibitors - no centrifugation required during purification. The 96-well format integrates with KingFisher Flex, Tecan Fluent, and Hamilton STAR liquid-handling platforms, enabling fully automated extraction of both RNA viruses (SARS-CoV-2, influenza, HIV) and DNA viruses (adenovirus, herpesvirus, parvovirus) from 96 samples per run. Choose the magnetic bead format for viral DNA/RNA co-extraction when processing 48+ samples per run, when a compatible automation platform is available, or when the program requires EUA-associated workflows validated for SARS-CoV-2 or other respiratory panel targets.
&nbsp;
<h2 dir="ltr">What you will find:</h2>
&nbsp;
<ul>
<li dir="ltr" aria-level="1">
Magbio HighPrep Viral-Bacterial DNA &amp; RNA Kit (HVB-DR0): Scalable magnetic bead chemistry optimized for the simultaneous extraction of viral and bacterial nucleic acids from diverse fluid profiles.
</li>
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Magbio HighPrep Viral DNA &amp; RNA Kit (HPV-DR0): High-efficiency magnetic isolation systems engineered for the rapid purification of viral target vectors from fluid specimens.
</li>
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Magbio HighPrep Viral-Pathogen DNA &amp; RNA Kit (HPP-DR0): Specialized bead technology designed to maximize pathogen recovery and eliminate inhibitors from challenging biological matrices.
</li>
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Quick-DNA/RNA Viral MagBead (R2140): Advanced magnetic-bead separation configurations built for fast, high-purity co-purification of total viral nucleic acids.
</li>
</ul>
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<h2>How to Choose a Magnetic Bead Viral DNA/RNA Co-Extraction Kit</h2>
&nbsp;
Automation Platform Compatibility
Confirm the kit's automation scripts are available for your specific platform before purchase. The Quick-DNA/RNA Viral MagBead Kit is used in Zymo Research's SARS-CoV-2 EUA workflow and is compatible with KingFisher and other major liquid-handling platforms; contact MBP's technical team or Zymo Research's automation support for current script availability. For Tecan Fluent or Hamilton STAR, platform-specific script development or adaptation may be required.
DNA/RNA Shield as the Collection Medium
The Quick-DNA/RNA Viral MagBead Kit is designed around DNA/RNA Shield as the sample collection, inactivation, and storage medium. Swabs or other samples stabilized in DNA/RNA Shield load directly into the extraction protocol without additional neutralization steps. For programs using VTM (viral transport medium), UTM, or PBS as collection media, confirm compatibility with the kit's lysis buffer by testing spike-in recovery before adopting at scale.
Carrier RNA Requirement
Unlike the QIAGEN QIAamp Viral RNA Mini Kit, the Quick-DNA/RNA Viral MagBead Kit does not require the user to prepare and add carrier RNA to the lysis buffer - the kit's buffer system is formulated for complete lysis and efficient nucleic acid binding without this step. Eliminating the carrier RNA preparation step reduces per-batch setup time and removes one source of inter-batch variability in high-throughput automated workflows.
Nucleic Acid Size Recovery Range
Confirm the kit recovers the size range needed for your downstream application. The Quick-DNA/RNA Viral MagBead Kit binds nucleic acids from &gt;50 nt to &gt;200 kb - covering small viral RNAs (miRNA-sized fragments from viral genomes), standard RT-qPCR amplicon targets, and full-length viral genomes for metagenomic NGS. Applications requiring recovery of very short fragments (&lt;50 nt) need a kit specifically validated for that range.
Regulatory Requirements
For IVD diagnostic use or regulatory submissions, confirm the kit's current regulatory status. The Quick-DNA/RNA Viral MagBead Kit has been used in EUA workflows; its current authorizations and intended uses may have evolved since initial authorization. Always verify directly with Zymo Research or MBP's regulatory affairs team for current compliance documentation.
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<h2>Specifications Context</h2>
&nbsp;
The Quick-DNA/RNA Viral MagBead Kit binds small (&gt;50 nt) and large (&gt;200 kb) DNA and RNA to magnetic beads and elutes high-quality nucleic acids ready for NGS, hybridization-based detection, and RT-qPCR. The kit is used in Zymo Research's SARS-CoV-2 EUA extraction workflow and has been adopted in published multiplex respiratory panel methods and pan-pathogen metagenomics protocols. A published PMC study on integrated DNA and RNA extraction from viral pathogens causing acute respiratory infections demonstrated that magnetic bead-based co-extraction achieved equivalent or superior sensitivity to spin-column formats for both RSV (RNA virus) and adenovirus (DNA virus) from the same nasopharyngeal swab input. Magnetic bead viral co-extraction is the standard format for large public health reference laboratories and clinical metagenomics programs processing 96-1,500+ samples per day across outbreak response and surveillance networks.
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Contact the helpful <a href="https://mbpinc.net/contact-us">team at MBP</a> today to request a quote for your specific research requirements.

Viral DNA/RNA Kit - Performance Data

Viral DNA/RNA Kit - Sensitivity

Comparative Data - How do we fare against key competitors?

Magbio HighPrep Viral DNA & RNA Kit

HighPrep Viral DNA &amp; RNA Kit — HPV-DR0 by MagBio Genomics — isolates total viral nucleic acids (DNA and RNA) from whole blood, serum, plasma, saliva, nasopharyngeal swabs, and other body fluids using MAG-S1 magnetic beads, with 200–400 µL input and 30–100 µL elution in nuclease-free water. Optimized for SARS-CoV-2 RNA and compatible with KingFisher Flex automation (23 min) and other liquid handling workstations; no organic solvents required. Available from MBP in 5, 96, and 384 prep sizes — order via <a href="https://www.mbpinc.net/quickorder">Quick Order</a> or contact <a href="mailto:customerservice@mbpinc.net">customerservice@mbpinc.net</a>.

Purification time

HighPrep Viral DNA & RNA Kit (5 preps)

HighPrep Viral DNA & RNA Kit (96 preps)

HighPrep Viral DNA & RNA Kit (384 preps)

<h2>What are Magnetic Bead Viral RNA Extraction Kits?</h2>
&nbsp;
Magnetic bead viral RNA extraction kits purify viral RNA from cell-free biological matrices - plasma, serum, nasopharyngeal swabs, urine, saliva, blood, and cell culture supernatant - by binding viral nucleic acids to paramagnetic silica-coated beads during chaotropic lysis. A magnetic field captures bead-RNA complexes during wash steps, eliminating centrifugation, and purified viral RNA elutes in 20-50 ul of RNase-free water or elution buffer suitable for direct use in RT-qPCR, RT-LAMP, and next-generation sequencing. The 96-well plate format processes all samples in a single run on a compatible liquid-handling robot, making this the standard choice for surveillance programs, diagnostic batch processing, and clinical biobank workflows. Choose a magnetic bead viral RNA kit when daily sample volumes exceed 24 extractions per session, when automation infrastructure is available, or when viral loads are low and maximum sensitivity from a small elution volume is required.
&nbsp;
<h2 dir="ltr">What you will find:</h2>
&nbsp;
<ul>
<li>Magbio HighPrep Viral RNA Kit KingFisher for seamless, automated viral RNA extraction using specialized superparamagnetic bead technology.</li>
<li>KingFisher-compatible magnetic bead workflows designed for high-throughput pathogen processing.</li>
<li>Automation-ready viral RNA purification solutions that reduce manual handling and improve laboratory efficiency.</li>
<li>Magnetic bead-based extraction systems for reliable recovery of viral nucleic acids from diverse sample types.</li>
<li>High-quality viral RNA isolation products suitable for RT-PCR, qPCR, sequencing, and molecular diagnostics applications.</li>
<li>Scalable pathogen extraction kits optimized for routine testing, surveillance, and research workflows.</li>
</ul>
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<h2>How to Choose a Magnetic Bead Viral RNA Extraction Kit</h2>
&nbsp;
Automation Platform Compatibility
Confirm the kit provides validated automation scripts for your instrument before purchase. Zymo Research Quick-DNA/RNA Viral MagBead kits support Tecan Fluent, Hamilton STAR, and Beckman Biomek; Thermo Fisher MagMAX Viral/Pathogen kits are validated on the KingFisher Flex and Duo systems. Generic bead kits without platform-specific scripts require in-house protocol development that adds weeks of validation time.
RNA-Only vs. DNA/RNA Co-Extraction
For pan-pathogen surveillance panels covering both RNA viruses (influenza, SARS-CoV-2, RSV) and DNA viruses (EBV, CMV, adenovirus, HPV), select a kit explicitly validated for DNA/RNA co-extraction. RNA-only kits use binding conditions that discriminate against dsDNA and will underperform on DNA viral targets.
Sample Input Volume and Matrix
Standard magnetic bead viral RNA kits support 100-200 ul of plasma, serum, or swab eluate per well. For low-viral-load samples where concentrating a larger starting volume is critical, verify the kit protocol for 500 ul input per well and confirm bead volume scales proportionally. Samples stabilized in Zymo DNA/RNA Shield can be directly loaded without an additional inactivation step.
Elution Volume
A 20-50 ul elution concentrates viral RNA from a standard 200 ul input by 4-10-fold relative to the original matrix, improving RT-qPCR sensitivity by 0.5-1.5 Ct. For sequencing applications, a 50-100 ul elution recovers more total RNA mass, which is more important than concentration for library input requirements.
Carrier RNA
Confirm the kit includes carrier RNA in the lysis buffer for low-titer specimens. For samples with expected viral copies &lt; 1x10^3/ml, carrier RNA supplementation is not optional - it is the difference between detectable and non-detectable results.
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<h2>Specifications Context</h2>
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Performance benchmarks: &gt;=70% RNA recovery measured by spike-in controls, eluate A260/A280 &gt;= 1.7, and Ct within 2 cycles of reference extraction. Magnetic bead-based extraction has been benchmarked against the QIAGEN QIAcube commercial platform and shown comparable RT-qPCR sensitivity for SARS-CoV-2 N-gene and E-gene targets, as reported in published peer-reviewed diagnostic studies. Zymo Research Quick-DNA/RNA Viral MagBead kits (R2140-E, R2141-E) hold Emergency Use Authorization and CE-IVD designation for diagnostic use, and are used in SARS-CoV-2 clinical workflows. Store extracted viral RNA at -70C to -80C; pre-extraction sample stabilization with DNA/RNA Shield enables ambient-temperature transport for up to 30 days without loss of RNA integrity.
<section class="mbp-contact-cta">
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MBP's specialist team can help match kit chemistry, format, and throughput to your sample type and downstream application.&nbsp;<a href="https://mbpinc.net/contact-us">Contact the MBP team</a> for personalized guidance.
</section>

HighPrep Viral RNA Kit (KF Format)

Product Fact Sheet - HighPrep Viral RNA Kit

Magbio HighPrep Viral RNA Kit KingFisher

The HighPrep Viral RNA Kit KingFisher Format by MagBio Genomics extracts viral RNA from 200 µL of nasopharyngeal swabs, whole blood, serum, plasma, and saliva in 23 minutes on KingFisher™ Flex (MVP_2Wash_200_Flex program). No organic solvents required. Optimized for SARS-CoV-2 RNA isolation. Compatible with RT-qPCR, PCR, NGS, and viral load monitoring workflows.

HighPrep Viral RNA Kit KingFisher™ Format (96 Preps)

HighPrep Viral RNA Kit KingFisher™ Format (2000 Preps)

HighPrep Viral/Bacterial DNA/RNA Kit

Magbio HighPrep Viral-Bacterial DNA & RNA Kit

HighPrep Viral-Bacterial DNA &amp; RNA Kit by MagBio Genomics is a magnetic bead-based co-isolation system for viral and bacterial DNA and RNA from whole blood, serum, plasma, saliva, and nasopharyngeal swabs, running in 23 minutes on the KingFisher Flex platform — available in 96-prep and 384-prep formats.

HighPrep Viral-Bacterial DNA & RNA Kit (5 preps)

HighPrep Viral-Bacterial DNA & RNA Kit (96 preps)

HighPrep Viral-Bacterial DNA & RNA Kit (384 preps)

HighPrep Viral/Pathogen DNA/RNA Kit

Magbio HighPrep Viral-Pathogen DNA & RNA Kit

MagBio HighPrep Viral-Pathogen DNA & RNA Kit by MagBio Genomics: magnetic bead-based simultaneous extraction of viral, bacterial, and fungal DNA and RNA from blood, plasma, serum, saliva, urine, and swabs. MAG-S1 beads; ~52 min on KingFisher Flex with ready-made script. 96-prep and 384-prep formats. RT-qPCR, PCR, and NGS compatible.

HighPrep Viral-Pathogen DNA & RNA Kit (5 preps)

HighPrep Viral-Pathogen DNA & RNA Kit (96 preps)

HighPrep Viral-Pathogen DNA & RNA Kit (384 preps)

DNA normalization and Concentration

<h2>What is DNA normalization and concentration for NGS?</h2>
&nbsp;
DNA normalization for NGS is the process of adjusting all individual indexed sequencing libraries to the same molar concentration before pooling them into a single multiplexed sequencing run, so that each library contributes approximately the same number of sequencing reads to the total run output. Concentration may also be needed when a library is too dilute after cleanup or elution. SPRI (solid-phase reversible immobilization) magnetic bead-based cleanup, most commonly using AMPure XP beads, is the standard method for post-library-prep cleanup, size selection, and concentration in NGS workflows.
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<h2 dir="ltr">What you will find:</h2>
&nbsp;
<ul>
<li dir="ltr" style="font-family: arial, helvetica, sans-serif;" aria-level="1">
Magbio MagQuant Plus DNA Kit: for automated, high-throughput nucleic acid concentration and normalization workflows
</li>
</ul>
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<h2>How to normalize and concentrate NGS libraries</h2>
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Quantify each library by qPCR to calculate molar concentration accurately
Kapa Library Quantification qPCR kits or equivalent measure the amplifiable, adapter-ligated molecules in a library, providing a molar concentration based on insert size that can be used to pool libraries at equal molar ratios. Fluorometric quantitation gives mass per volume but not molar concentration, and libraries with different insert sizes have different mass-to-moles conversion factors.
Calculate library molar concentration using measured mass and average insert size
If molar quantitation by qPCR is not available, the molar concentration of a library can be estimated from its fluorometric mass concentration and the average insert size from Bioanalyzer or TapeStation: molar concentration (nM) = (mass in ng/&micro;l &times; 10^6) / (insert size in bp &times; 660 g/mol/bp). This converts mass to moles using the average molecular weight per base pair.
Pool indexed libraries at equal molar ratios for balanced depth
After calculating the molar concentration of each library, pool volumes delivering equal moles of each library into the final pool. Even small quantitation errors translate into coverage imbalances between samples in the sequencing output.
Use SPRI bead cleanup to concentrate libraries and remove adapter dimers
SPRI bead cleanup with AMPure XP beads at the appropriate bead-to-sample ratio selects for DNA fragments above a size cutoff while removing smaller adapter dimers and free adapter molecules. The final elution in a smaller volume of buffer concentrates the library. The bead ratio determines the minimum retained fragment size, with higher ratios retaining smaller fragments.
Verify the pooled library before sequencing
After pooling and final SPRI cleanup, measure the pooled library by qPCR and Bioanalyzer to confirm molar concentration and size distribution before loading, since loading concentration determines cluster density and affects sequencing performance.
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<h2>Specifications context</h2>
&nbsp;
AMPure XP SPRI beads use polyethylene glycol and sodium chloride to precipitate DNA onto paramagnetic beads in a size-dependent manner, making the bead-to-sample volume ratio the key parameter for controlling the minimum retained fragment size. As of 2026, automated bead-based normalization kits that combine quantitation and normalization remain available for high-throughput settings, though most academic labs perform manual quantitation and normalization before pooling.
Browse through the catalog and <a href="https://mbpinc.net/contact-us">contact the expert team</a> to book high-quality DNA normalization and concentration products today.

MagQuant_Plus_DNA Kit V2 - Protocol_REV3

Magbio MagQuant Plus DNA Kit V2

MQP-50000 by MagBio Genomics is the MagQuant Plus DNA Kit V2, a magnetic bead kit for DNA normalization and quantitation in NGS, amplicon, and genomic DNA workflows. No centrifugation, no standard curve required; 25–50 µL elution volume; available in 96-, 384-, and 1920-prep sizes.

DNA input

DNA Purity Requirements

Application

MagQuant Plus DNA Kit V2 (10 Preps)

MagQuant Plus DNA Kit V2 (96 Preps)

MagQuant Plus DNA Kit V2 (384 Preps)

MagQuant Plus DNA Kit V2 (1920 Preps)

MagQuant Plus DNA Kit V2 (5000 Preps)

Storage Boxes & Racks

<h2 data-section-id="1hv97bw" data-start="0" data-end="47">What Are Laboratory Storage Boxes and Racks?</h2>
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Laboratory storage boxes and racks are essential organizational systems used to store, organize, and protect cryogenic vials, microcentrifuge tubes, centrifuge tubes, and microscope slides across freezers, cold rooms, and benchtop environments. Storage boxes are typically lidded, grid-based containers used for long-term sample organization in ultra-low temperature conditions, while racks are open-frame supports used for active handling during laboratory workflows such as pipetting, vortexing, and reaction setup.
Cryogenic storage boxes are commonly designed to hold 81 vials (9&times;9 format) or 100 vials (10&times;10 format), and are compatible with storage conditions ranging from &ndash;196 &deg;C in liquid nitrogen vapor phase to +121 &deg;C for autoclave sterilization (depending on material). Tube racks, on the other hand, provide stable upright positioning of tubes during active benchwork and are not primarily intended for long-term freezer storage.
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<h2 dir="ltr">What you will find:</h2>
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<ul>
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Cryogenic storage boxes for vials and microtubes
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<li dir="ltr" aria-level="1">
Freezer storage boxes for -20&deg;C and -80&deg;C applications
</li>
<li dir="ltr" aria-level="1">
PCR tube racks for 0.2 mL tubes and strips
</li>
<li dir="ltr" aria-level="1">
Microcentrifuge tube racks for 0.5 mL to 2 mL tubes
</li>
<li dir="ltr" aria-level="1">
Polypropylene (PP) autoclavable storage boxes
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<li dir="ltr" aria-level="1">
Stackable storage boxes for space-saving organization
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Hinged lid storage boxes for secure sample protection
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Color-coded racks for easy sample identification
</li>
</ul>
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<h2 data-section-id="flyrii" data-start="1159" data-end="1199">How to Choose Storage Boxes and Racks</h2>
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Vial Format and Capacity
The first selection criterion is compatibility with tube size and grid layout. The most common format is the 81-place (9&times;9) box designed for 1.0&ndash;2.0 mL cryovials. Smaller or specialized formats may accommodate 5 mL tubes or different vial diameters depending on grid spacing. Proper matching ensures secure fit, easy retrieval, and consistent sample organization in high-density storage systems.
Temperature Range
Material selection determines allowable storage conditions. Polycarbonate cryogenic boxes are the most versatile, supporting temperatures from liquid nitrogen levels (&ndash;196 &deg;C) through &ndash;80 &deg;C freezer storage and up to autoclave sterilization at +121 &deg;C. Cardboard freezer boxes with moisture-resistant coating are designed for economical freezer storage and can withstand ultra-low temperatures, but they are not suitable for autoclaving or long-term moisture exposure.
Tube Rack Materials and Use
Polypropylene racks are widely used because they are autoclavable and chemically resistant, making them suitable for sterile workflows. ABS and polystyrene racks provide lower-cost alternatives for general laboratory bench use but are not designed for autoclave conditions. For freezer organization, stainless steel racks are often used to hold multiple cryoboxes within &ndash;80 &deg;C upright freezer systems, improving accessibility and spatial organization.
Slide Storage Boxes
Microscope slide storage boxes are designed to protect standard 25 &times; 75 mm slides. They are available in 25-, 50-, and 100-slide capacities. Polypropylene versions are autoclavable and suitable for sterilized workflows, while fiberboard or ABS versions are typically used for room-temperature archival storage and transport.
Color Coding and Sample Identification
Color-coded storage boxes are widely used in biobanking and high-throughput laboratories to quickly differentiate sample groups without opening boxes or reading labels at freezer temperatures. Common systems include multiple lid colors paired with alphanumeric grids inside the box, enabling precise sample tracking and retrieval in large inventories.
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<h2 data-section-id="1jl751w" data-start="4067" data-end="4092">Specifications Context</h2>
&nbsp;
Modern polycarbonate cryogenic storage boxes are engineered for extreme temperature stability, typically rated from &ndash;196 &deg;C to +121 &deg;C, allowing use across liquid nitrogen vapor phase storage, &ndash;80 &deg;C freezers, and autoclave sterilization cycles. Cardboard freezer boxes are coated to resist moisture ingress and are optimized for cost-efficient high-density storage in ultra-low temperature environments.
The 81-place (9&times;9 grid) polycarbonate cryobox remains the standard format in most biorepositories and clinical research facilities due to its compatibility with SBS footprint freezer systems and automated inventory tracking workflows. These systems are widely used in genomics, cell banking, and pharmaceutical research environments.
For product details, specifications, or bulk ordering support, <a href="https://mbpinc.net/contact-us">the MBP team can help you</a> choose the right storage solution for your laboratory needs.

MyMag 96X Magnetic Plate

MyMag 96X Magnetic Plate (MYMAG-96X) by MBP is a 96-well magnetic separation plate for bead-based nucleic acid extraction. Accommodates up to 500 µL sample volume and 2 mL total reaction volume per well. Compatible with manual pipetting and automated liquid-handling workstations with a standard SBS footprint.

Components

Storage

Stability

Shipping Condition

Storage Condition

Automated Purification Systems

<h2>What Are Automated Purification Systems?</h2>
&nbsp;
Automated purification systems are integrated chromatography instruments that combine a multi-channel solvent delivery pump, a sample injection module, a chromatography column holder (accepting prepacked cartridges or reusable columns), a UV/Vis (and optionally ELSD or mass detector) detection system, and an automated fraction collector into a single controlled platform. The system runs gradient elution programs that change solvent composition over time, separating sample components by their differential affinity for the stationary phase. UV signal peaks trigger fraction collection into numbered tubes or microplates, eliminating the need for the operator to monitor the separation and manually collect fractions. Mass-directed systems add an inline mass spectrometer to trigger fraction collection on a specific molecular mass rather than UV absorbance, enabling selective collection of the target compound even when it co-elutes with impurities of similar UV absorption. Specify an automated purification system when your lab runs more than 3 to 5 flash chromatography purifications per day; the time saved on each run compounds rapidly and improves fraction quality through consistent, reproducible gradient programming.
&nbsp;
<h2 dir="ltr">What You Will Find:</h2>
&nbsp;
<ul>
<li data-section-id="1xaq5zs" data-start="25" data-end="248">Compact and high-throughput magnetic bead-based instruments, including IsoPure&trade; Mini, IsoPure&trade; 24, IsoPure&trade; 96, and Nucleic Acid Purifier 16 systems for automated nucleic acid purification.</li>
<li data-section-id="124t8zs" data-start="249" data-end="383">Compatible 24-well and 96-well deep-well plates and elution plates for automated purification workflows.</li>
<li data-section-id="ucx4qa" data-start="384" data-end="516">Replacement magnetic tip combs for IsoPure&trade; Mini, IsoPure&trade; 24, and IsoPure&trade; 96 automated purification systems.</li>
<li data-section-id="15pcqjt" data-start="517" data-end="657">Reagent vessels and aluminum sample racks designed for efficient sample loading and workflow organization.</li>
<li data-section-id="4rzy3m" data-start="658" data-end="817" data-is-last-node=""><a href="https://mbpinc.net/equipments/purification-and-separation-equipment/automated-purification-systems/automated-purification-system-accessories">System Accessories</a>, including Tablets, demo cases, and other compatible accessories to support the setup, operation, and maintenance of automated purification systems.</li>
</ul>
&nbsp;
<h2>How to Choose an Automated Purification System</h2>
&nbsp;
Flash chromatography vs. preparative HPLC
Automated flash chromatography systems (operating at 5 to 30 bar with spherical 25 to 100 micron silica or C18 cartridges) are optimized for fast, cost-effective purification of 0.1 to 10 g samples with throughputs of 3 to 10 runs per day. Preparative HPLC systems (operating at 50 to 300 bar with 5 to 25 micron particle columns) provide higher resolution for complex mixtures, smaller sample loads (mg to g scale), and are required when flash chromatography cannot resolve closely similar compounds. Some systems integrate both flash and prep HPLC capability in one instrument.
Sample load and column capacity
Match the column loading to your typical sample mass. Standard flash cartridges in 4 g, 12 g, 25 g, 40 g, 80 g, and 120 g silica sizes handle sample loads of roughly 0.04 to 1.2 g on normal-phase silica. Reversed-phase C18 cartridges handle lower loads per gram of silica. For larger sample loads (5 to 100 g), large-diameter columns or multi-injection protocols are used. Confirm the system's maximum column size and flow rate capacity against your typical sample mass.
Detection: UV/Vis vs. ELSD vs. mass directed
UV/Vis detection (monitoring at 254 nm and 280 nm) is standard and sufficient for compounds with a chromophore (most synthetic products). Evaporative light scattering detection (ELSD) is added for compounds with poor UV absorption (lipids, carbohydrates, alkyl chains). Mass-directed purification adds an inline single-quadrupole mass spectrometer that triggers fraction collection only when the target mass is detected; this is the highest-selectivity option for purifying one compound from a complex mixture, but at significantly higher instrument cost.
Number of solvent lines
Entry-level systems use two solvent lines (binary gradient). Advanced systems provide four solvent lines (quaternary gradient), enabling more complex separation strategies, modifier additions (e.g., acetic acid or ammonium formate in reversed-phase), and reduced operator setup time for multi-method labs. For most flash chromatography in synthetic chemistry, a binary gradient (organic/non-polar + polar modifier) is sufficient.
Software and workflow integration
Automated systems vary widely in software capability: basic systems provide gradient programming and peak detection; advanced platforms add automatic injection, queue management for multiple samples, solvent level monitoring, LIMS connectivity, and 21 CFR Part 11 compliance for regulated pharmaceutical environments. For open-access use in multi-chemist departments, queue-based software allowing each user to submit samples independently increases throughput.
&nbsp;
<h2>Specifications Context</h2>
&nbsp;
Column and cartridge consumables are a significant ongoing cost for automated purification systems; prepacked silica cartridges for flash systems are single-use or limited-use. Confirm cartridge availability and pricing for the specific system before purchase, as some systems lock users to proprietary cartridges at premium pricing while others accept standard-thread cartridges from multiple suppliers. Solvent consumption (L/run) scales with column size and flow rate; larger cartridges and longer gradients use more solvent. For high-throughput labs, solvent waste management (evaporation, recycling, or disposal) is a practical operational consideration. UV detection wavelength settings (254 nm for aromatic compounds, 210 to 220 nm for carbonyl-containing compounds) should be confirmed for your compound class to avoid missing low-UV-absorbing peaks.&nbsp;
&nbsp;
Complete your purification setup today&mdash;browse our accessories collection and <a href="https://mbpinc.net/contact-us">contact the MBP team</a> for a quote.

Nucleic Acid Purifier 16 (1 Unit)

NAP16 by MagBio Genomics is a compact automated nucleic acid purifier for up to 16 samples per run using magnetic bead extraction, with a 50–1000 µL sample volume range, 10–60 min processing time, lysis/elution temperatures up to 120°C, >95% bead recovery, and built-in UVC sterilization.

Capacity / Sample Volume 16 samples / 20µl to 1000µl Magnetic bead recovery rate

Lysis temperature range

Elution temperature range

Display

Programming control

Program memory

Communication ports

Contamination Control

Electrical Input

Dimensions

DNA/PCR

<h2>What is DNA/PCR Sequencing Cleanup?</h2>
&nbsp;
DNA/PCR sequencing cleanup purifies PCR-amplified NGS library products - indexed Illumina libraries after amplification, amplicon sequencing PCR products (16S rRNA, ITS, targeted gene panels), and long-range PCR products for long-read sequencing - removing residual PCR primers, dNTPs, thermostable polymerase, betaine, DMSO, BSA, and PCR buffer salts that inhibit sequencing cluster generation, flow cell loading, and library quantification. Perform SPRI bead cleanup after every PCR amplification step in library preparation - residual primers generate non-informative sequencing reads, betaine carryover inhibits cluster generation chemistry, and thermostable polymerase coats flow cell surfaces, reducing cluster density and data yield.
&nbsp;
<h2>What you will find</h2>
&nbsp;
<ul>
<li>Magbio HighPrep&trade; PCR: A highly flexible, bead-based reagent that simplifies post-PCR cleanup and dual-sided size selection, fitting seamlessly into your high-throughput automated platforms.</li>
<li>HighPrep&trade; PCR PB Kit: Specifically optimized for the rigorous demands of Pacific Biosciences (PacBio) workflows, this kit ensures you recover the long-read fragments your research depends on.</li>
<li>Selective Contaminant Depletion: Our buffers are engineered to remove salts and polymerases without the stress of centrifugation, delivering transfection-grade purity in every sample.</li>
</ul>
&nbsp;
<h2>How to Choose a DNA/PCR Sequencing Cleanup Reagent</h2>
&nbsp;
Bead Ratio for Target Amplicon Size
The bead-to-sample ratio determines the minimum fragment size retained. At 0.8x: retains &gt;=300 bp; removes primers and adapter dimers; best for amplicons &gt;=300 bp (16S V3-V4, ITS2). At 0.9x: retains &gt;=200 bp; removes primers and adapter dimers; standard for indexed library amplicons. At 1.0x: retains &gt;=150 bp; removes primers; useful for short-insert libraries (100-200 bp). At 1.8x: retains &gt;=100 bp; maximum primer removal; over-cleaning for library amplicons. Always calibrate the bead ratio using a test library at your target amplicon size before processing study samples; empirical calibration is required because bead lot performance and PEG concentrations vary.
Double-Side SPRI After PCR
For amplicon libraries where the PCR product range is wide (multiple bands) or where large amplification artifacts must be removed alongside primers, double-sided SPRI after PCR selects the target amplicon precisely: the first step removes amplification artifacts above the target size; the second step retains the target amplicon and discards primers and primer dimers.
Bead-Based vs. Spin Column After PCR
AMPure XP beads are preferred for high-throughput 96-well plate PCR cleanup in amplicon sequencing workflows where 96-384 individual PCR amplicons must be cleaned before pooling. Spin columns (Zymo DNA Clean &amp; Concentrator-5) are used for small-batch amplicon cleanup when concentrated eluate in 6-30 &micro;l is needed before capillary electrophoresis or other downstream analysis.
Betaine and DMSO Removal
If your PCR protocol includes betaine (1-2 M) or DMSO (1-5%), confirm complete removal by checking that the post-cleanup DNA solution is free of unusual viscosity (indicating residual betaine). At the standard bead ratio, betaine and DMSO are completely removed during the 2x 80% ethanol wash steps. If betaine or DMSO carryover is suspected (reduced sequencing cluster density), add 200 &micro;l ethanol wash before elution.
Amplicon Sequencing Pool Cleanup
After individually cleaning and quantifying each amplicon library by Qubit HS, pool at equimolar ratios before the final SPRI cleanup of the pool. Final pool cleanup at 0.9x removes any residual primer from individual library cleanup steps and normalizes the final pool for sequencing loading.
&nbsp;
<h2>Specifications Context</h2>
HighPrep&trade; PCR uses SPRI magnetic bead technology for post-PCR cleanup and DNA size selection. Adjustable bead-to-sample ratios enable efficient removal of primers, primer dimers, adapter dimers, nucleotides, enzymes, and buffer components while selectively retaining target DNA fragments. Standard ratios support PCR product cleanup, while dual-sided selections provide precise library size distribution for NGS workflows. HighPrep&trade; PCR PB Kit is optimized for PacBio sequencing, maximizing recovery of long DNA fragments while depleting smaller contaminants. The centrifugation-free workflow supports both manual and automated processing and is compatible with Illumina, ONT, and PacBio library preparation.
&nbsp;
Ready to refine your library? The MBP team is here to help&mdash;<a href="https://mbpinc.net/contact-us">contact us</a> today for a personalized quote on our PCR size selection reagents.

Magbio HighPrep PCR

HighPrep PCR by MagBio Genomics is a paramagnetic bead reagent for post-PCR cleanup and NGS-ready DNA size selection, retaining fragments ≥100 bp at 1.8× ratio, with >70% DNA recovery, ≥15 µL elution, 18-month shelf life at 2–8°C, and KingFisher Flex automation compatibility.

Starting amount

RNA recovery

HighPrep PCR (1 mL)

HighPrep PCR (5 mL)

HighPrep PCR (50 mL)

HighPrep PCR (250 mL)

HighPrep PCR (500 mL)

<h2>What Are Magnetic Bead HMW DNA Extraction Kits?</h2>
&nbsp;
A magnetic bead HMW DNA extraction kit uses Solid Phase Reversible Immobilization (SPRI)-type magnetic beads to bind genomic DNA released by gentle lysis, with a magnetic separator handling wash and elution steps in place of centrifugation, columns, or vacuum manifolds, producing fragment sizes in the 50-150 kb range depending on how beads are resuspended during elution. Related entities include PacBio Nanobind-type bead chemistry, KingFisher-compatible automated magnetic particle processors, A260/280 and A260/230 purity thresholds above 1.8, and downstream long-read sequencing library preparation for PacBio and Oxford Nanopore platforms. Choose magnetic bead HMW kits when fragment sizes in the 50-150 kb range meet your long-read sequencing needs, and you want to avoid centrifugation-based shearing.
&nbsp;
<h2>What you will find:</h2>
&nbsp;
<ul>
<li>Low-shear high molecular weight DNA isolation solutions using advanced paramagnetic bead technology, including the Magbio HighPrep HMW DNA Kit.</li>
<li>High-throughput magnetic bead-based extraction systems for simultaneous recovery of intact genomic DNA, including the Quick-DNA&trade; HMW Kit.</li>
<li>Workflow-friendly HMW DNA purification kits designed to preserve long DNA fragments for long-read sequencing applications.</li>
<li>Solutions compatible with manual and automated sample processing for efficient genomic DNA recovery.</li>
<li>HMW DNA extraction products suitable for genome assembly, structural variant analysis, and other advanced genomics workflows.</li>
</ul>
&nbsp;
<h2>How to Choose a Magnetic Bead HMW DNA Kit</h2>
&nbsp;
Bead Resuspension Method and Fragment Size Tradeoff
Fragment size from magnetic bead HMW kits depends on how beads are resuspended after washing: gentle tube tapping typically yields fragments in the 50-150 kb range, while vortexing produces somewhat smaller fragments (around 40-100 kb) but may improve recovery consistency. If your sequencing application benefits from the largest possible fragments (e.g., resolving large structural variants), prioritize tapping-based resuspension protocols even if yield is marginally lower.
Sample Input and Expected Yield
Magnetic bead HMW kits for blood, cells, and tissue typically specify inputs such as 200 ul of fresh/frozen whole blood, 1 million cells, or up to 8 mg of tissue, with a minimum yield around 3 ug of HMW gDNA&mdash;matching the input requirements of PacBio library preparation (around 1 ug above 30 kb) and Oxford Nanopore ligation kits (100 ng to 1.5 ug). Confirm your sample type matches a documented protocol within the kit family rather than assuming a single universal protocol.
No Centrifuge, Column, or Vacuum Required
Unlike silica spin-column or 96-well plate HMW approaches, magnetic bead HMW kits eliminate centrifugation, columns, and vacuum manifolds entirely, relying only on a magnetic separator for all wash and elution steps. This simplifies equipment requirements for labs without access to specialized centrifuge rotors, though a magnetic stand or automated magnetic particle processor is still required.
Purity Ratios and RNA Removal
A260/280 and A260/230 ratios greater than 1.8 are generally preferred for HMW DNA from magnetic bead kits, with near-complete RNA removal reported as a feature of bead-based HMW chemistry. Ratios below this threshold can indicate protein or salt contamination requiring troubleshooting before proceeding to expensive long-read library preparation.
&nbsp;
<h2>Specifications Context</h2>
&nbsp;
The defining specifications for magnetic bead HMW DNA extraction are the fragment size achievable via the bead resuspension method chosen, sample-specific input requirements relative to the kit's documented minimum yield, and purity ratios above 1.8 for both A260/280 and A260/230. A kit yielding around 3 ug of DNA in the 50-150 kb range from 200 ul whole blood, 1 million cells, or up to 8 mg tissue meets standard PacBio and Nanopore library preparation inputs without centrifugation.&nbsp;
&nbsp;
<section class="mbp-contact-cta">
MBP's specialist team can help match kit chemistry, format, and throughput to your sample type and downstream application.&nbsp;<a href="https://mbpinc.net/contact-us">Contact the MBP team</a> for personalized guidance.
</section>

Magbio HighPrep HMW DNA Kit

HighPrep HMW DNA Kit by MagBio Genomics is a magnetic bead-based system that isolates high molecular weight DNA (50–300+ kb) with A260/A280 and A260/A230 &gt;1.7 from blood, tissue, cells, and bacteria — yielding ≥10 µg from 10 mg tissue — for long-read sequencing, nanopore, microarray, and genotyping applications.

Starting Material (Diverse Sample Types)

Process Method

Purification Method

Size Range

Purity

Yield

Automated Extraction on Kingfi sher™ Flex

Manual Extraction

Downstream Applications

HighPrep HMW DNA Kit (5 preps)

HighPrep HMW DNA Kit (96 preps)

HighPrep HMW DNA Kit (984 preps)

MagBead

<h2>What Are Magnetic Bead Plasmid DNA Extraction Kits?</h2>
&nbsp;
Magnetic bead plasmid DNA kits use superparamagnetic nanoparticles, typically silica-coated or anion-exchange-functionalized, suspended in optimized binding buffers to capture plasmid DNA from bacterial lysate. After alkaline lysis of E. coli culture (0.5-5 mL per reaction), the beads bind DNA; an external magnetic field then immobilizes the beads so supernatant, RNA, and proteins are washed away without centrifugation. The purified DNA is eluted in water or low-salt buffer and is ready for downstream use. Throughput scales from single-tube manual processing to 96-well plate automation on KingFisher Duo, MagnetaPure 32, or ASSIST PLUS liquid handlers. Choose magnetic bead kits when your lab runs plasmid minipreps at scale (24+ samples/run) or when centrifuge-free automation is required.
&nbsp;
<h2>What you will find:</h2>
&nbsp;
<ul>
<li>Magbio HighPrep Plasmid DNA Plus Kit for rapid, automated plasmid purification using high-binding paramagnetic particle technology.</li>
<li>Zyppy&trade;-96 Plasmid MagPrep Kit for scalable magnetic separation of high-purity vector constructs.</li>
<li>Zyppy-96 Plasmid MagBead Prep Kit for faster, column-free plasmid isolation.</li>
<li>Magnetic bead-based plasmid purification solutions compatible with high-throughput laboratory workflows.</li>
<li>Column-free plasmid DNA extraction systems that simplify processing and reduce hands-on time.</li>
<li>Products designed for efficient recovery of clean plasmid DNA for cloning, sequencing, and transfection applications.</li>
<li>Automation-friendly plasmid preparation kits suitable for 96-well and large-batch sample processing.</li>
</ul>
&nbsp;
<h2>How to Choose Magnetic Bead Plasmid Kits</h2>
&nbsp;
Automation Platform Compatibility
Bead-based kits are designed for specific magnetic rod or liquid-handler platforms. Confirm compatibility before ordering: NucleoMag Plasmid kits are validated for MagnetaPure and IsoPure Mini; MagJET kits are optimized for the KingFisher series; MagMAX Pro HT kits are designed for high-throughput centrifuge-free workflows. Using a kit outside its validated platform may require buffer volume adjustments and is not supported by the manufacturer.
Bead Type and DNA Binding Capacity
Silica-coated magnetic beads use chaotropic binding chemistry similar to spin columns; anion-exchange-functionalized beads offer higher selectivity for covalently closed circular (CCC/supercoiled) plasmid. Standard miniprep bead kits bind 5-20 ug from 1.5 mL culture; scaled protocols for 5 mL can yield up to 50 ug. Check binding capacity against your expected yield to avoid saturation.
High-Copy vs Low-Copy Plasmid
Most bead-based kits are validated for standard high-copy plasmids (pUC, pBR322 derivatives). Low-copy constructs such as fosmids or BACs require longer lysis times and may need protocol modifications; check the kit's validated plasmid types before purchasing for non-standard vectors.
Elution Volume and Concentration
Bead protocols typically elute in 50-100 uL. If downstream transfection requires high DNA concentration, choose kits that support low-volume elution (50 uL) or perform a secondary concentration step. Check that the eluate is compatible with your downstream assay buffer conditions.
&nbsp;
<h2>Specifications Context</h2>
&nbsp;
Plasmid DNA purity from bead-based kits is evaluated by the A260/A280 ratio (target 1.8-2.0) and the A260/A230 ratio (&gt;1.8). Supercoiling percentage (measured by agarose gel densitometry) should exceed 80% for standard transfection applications. Automated 96-well bead workflows complete plasmid isolation in 30-60 minutes for a full plate, compared to 1-2 hours for centrifuge-based spin-column processing of the same number of samples. All kits are Research Use Only (RUO).
&nbsp;
<section class="mbp-contact-cta"></section>
MBP's specialist team can help match kit chemistry, format, and throughput to your sample type and downstream application.&nbsp;<a href="https://mbpinc.net/contact-us">Contact the MBP team</a> for personalized guidance.

Magbio HighPrep Plasmid DNA Plus Kit

The HighPrep Plasmid DNA Plus Kit by MagBio Genomics purifies plasmid DNA from 1.0–1.5 mL E. coli cultures using magnetic bead technology. High-copy yield ~10–15 µg; 50 µL elution volume; 96 preps completed in under 60 minutes. Supports plasmids, BACs, PACs, cosmids, and fosmids. Compatible with KingFisher™ Flex automation and downstream PCR, sequencing, NGS, and transfection.