Tubes & Sample Collection

Lysis and Collection Tubes

<h2 dir="ltr">What are Lysis and Collection Tubes?</h2>
 Lysis and collection tubes are pre-filled, single-use vessels containing a mechanical or chemical lysis matrix&mdash;typically combined with a nucleic acid preservative&mdash;that enable simultaneous sample disruption, stabilization, and transport in one container. They are used in DNA extraction, RNA extraction, metagenomics, microbiomics, environmental sampling, and bead-beating workflows for tissue, microbial pellets, swabs, and biological fluids. Bead formats include 0.1 mm, 0.5 mm, and 2.0 mm beads to match sample toughness. Choose lysis and collection tubes when your workflow requires homogenization of difficult-to-lyse samples and room-temperature nucleic acid preservation from collection through extraction.
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<h2 dir="ltr">What you will find:</h2>
&nbsp;
<ul>
<li dir="ltr" role="presentation">DNA/RNA stabilization lysis tubes for immediate sample preservation</li>
<li dir="ltr" role="presentation">Pre-filled bead beating tubes for microbial and tissue disruption</li>
<li dir="ltr" role="presentation">Swab-based lysis and collection tubes for clinical sampling</li>
<li dir="ltr" role="presentation">Microbial lysis tubes for bacteria, fungi, and environmental samples</li>
<li dir="ltr" role="presentation">Ready-to-process tubes for PCR, qPCR, and sequencing workflows</li>
<li dir="ltr" role="presentation">General-purpose molecular biology lysis and collection systems</li>
</ul>
<h2 dir="ltr"> How to Choose Lysis and Collection Tubes</h2>
 Bead Size and Matrix Bead diameter determines lysis efficiency for your matrix: 0.1 mm beads are suited for bacteria, yeast, and spores; 0.5 mm for most soft tissues and biofilms; 2.0 mm for tough plant and fibrous animal tissue. Select the matrix format that matches your homogenizer's speed and run time.
Preservative Chemistry Tubes pre-filled with DNA/RNA Shield (Zymo Research) stabilize both DNA and RNA at ambient temperature for up to one month, inactivate infectious agents including SARS-CoV-2, and are compatible with standard purification kits without reagent removal. Tubes with lysis buffer only stabilize for shorter intervals and may require cold-chain transport.
Sample Input Type Tissue lysis tubes handle 10&ndash;100 mg solid tissue; microbial lysis tubes are optimized for 200 &micro;L liquid culture or swab eluate. Using a microbial-format tube for high-mass tissue can clog beads and reduce yield.
Downstream Application For NGS, single-cell RNA-seq, or RT-PCR, choose RNA-stabilizing tubes (RNase-inhibiting chemistry). For 16S/ITS microbiome work, DNA-stabilized bead-beating tubes are sufficient. Confirm compatibility with your downstream extraction kit before ordering in bulk.
Volume Capacity Standard lysis tubes hold 0.5&ndash;2 mL fill volume. Confirm fill volume against your expected sample input; overfilling reduces lysis efficiency by limiting bead-to-sample contact.
<h2 dir="ltr"> Specifications Context</h2>
 Lysis and collection tubes pre-filled with DNA/RNA Shield are stabilized at ambient temperature (15&ndash;25 &deg;C) for up to 28 days per Zymo Research validation data. Samples rendered non-infectious on contact with the reagent are compatible with standard shipping under IATA Packing Instruction 650 (P650) and UN3373 Biological Substance Category B regulations. Homogenization is performed at &ge;4,000 rpm for 30&ndash;60 seconds; run time varies by homogenizer model (e.g., Benchmark BeadBug, Qiagen TissueLyser, MP Biomedicals FastPrep). As of 2026, tubes pre-filled with 2X concentrate DNA/RNA Shield are also available for samples with high aqueous volume. 
For procurement and bulk ordering, MBP accepts purchase orders and offers direct customer support &mdash; a consistent advantage over the automated queues of large distributors. Contact the <a href="https://mbpinc.net/contact-us" style="color: #236fa1; text-decoration: underline;">MBP team</a> to select the right lysis and collection format.

FAQ - MagCTL Collection Tube

MagCTL Collection Tube

MXCT by MagBio Genomics is a 5 mL guanidine-free MagCTL Collection Tube pre-filled with 1.2 mL CTL Medium™ for RNA (stable 8 days) and DNA (stable 45 days) preservation at room temperature, with FDA 510(k) clearance, CE/IVDR certification, and UKCA registration.

MXCT-100 = MagCTL Collection Tube (100 Tubes) 

Storage

Stability

Manufacturer

MagCTL Collection Tube (5 Tubes)

MagCTL Collection Tube (100 Tubes)

MagCTL Collection Tube (2500 Tubes)

Blood Collection Tubes

<h2>What are Blood Collection Tubes for Nucleic Acid Research?</h2>
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Blood collection tubes for nucleic acid research are evacuated tubes pre-filled with a lysis reagent or anticoagulant that preserve DNA and/or RNA from whole blood specimens collected by standard venipuncture. On blood draw, the lysis reagent immediately inactivates nucleases and preserves both genomic DNA and RNA&mdash;including transcriptomic expression profiles&mdash;from 3&ndash;6 mL of mammalian whole blood. They are used in gene expression analysis, next-generation sequencing, PCR-based molecular diagnostics, cell-free DNA (cfDNA) studies, and biobank archiving. Choose blood collection tubes specifically formulated for nucleic acid preservation when the sample cannot be processed within 2&ndash;4 hours of draw.
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<h2>What you will find:</h2>
&nbsp;
<ul>
<li>Vacuum blood collection tubes for standardized sample volumes</li>
<li>Capillary blood collection tubes for small-volume sampling</li>
<li>Pediatric and micro-collection tubes for difficult draws</li>
<li>Sterile single-use blood collection tubes for diagnostic safety</li>
<li>General-purpose clinical and laboratory blood sampling tubes</li>
</ul>
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<h2>How to Choose Blood Collection Tubes</h2>
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DNA vs RNA vs Dual Preservation
K2 EDTA tubes (lavender cap) prevent clotting and preserve cellular morphology for CBC and flow cytometry, but RNA degrades rapidly without additional stabilization. Blood RNA stabilization tubes preserve intracellular RNA expression profiles, while dual-preservation blood collection tubes stabilize both DNA and RNA simultaneously, enabling downstream molecular analysis from a single specimen.
Blood Volume Per Tube
Standard blood collection tubes typically hold 3 mL or 6 mL. Confirm the draw volume against your extraction kit's minimum input requirement. Many NGS and RT-PCR extraction kits require 1&ndash;3 mL of whole blood per reaction, making 3 mL tubes sufficient for many single downstream applications.
Processing Window
For immediate processing (within 2 hours), standard K2 EDTA tubes are generally suitable. For delayed processing or sample shipment, choose blood collection tubes specifically formulated to stabilize nucleic acids according to the manufacturer's validated storage conditions.
Anticoagulant Type
K2 EDTA is the preferred anticoagulant for most molecular biology applications, including PCR and NGS. K3 EDTA may be used in some automated laboratory systems. Heparin is a known PCR inhibitor and should generally be avoided for nucleic acid workflows. Citrate tubes are not typically used for nucleic acid preservation.
Regulatory Compliance
For clinical or regulatory-submission workflows, confirm whether the blood collection tube has the appropriate regulatory approval or clearance for your intended application. Research-use-only (RUO) products are not intended for diagnostic use unless specifically authorized.
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<h2>Specifications Context</h2>
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Standard evacuated blood collection tubes are commonly manufactured from medical-grade PET or glass. K2 EDTA tubes should be gently inverted 8&ndash;10 times immediately after collection to ensure complete anticoagulant mixing. Nucleic acid preservation tubes are available for both immediate processing and stabilized transport, depending on the manufacturer. DNA and RNA yield varies with donor characteristics, collection volume, storage conditions, and the extraction method used.
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Every accurate diagnosis starts with the right sample. Reach out to the <a href="https://mbpinc.net/contact-us">MBP team</a> today for expert guidance. MBP is a registered vendor for Howard Hughes Medical Institute, Vanderbilt University, and MD Anderson Cancer Center. PO and quote ordering are available directly.

Blood STASIS™-DNA/RNA - Handbook

Blood STASIS™-DNA/RNA - MSDS

Clinical Evaluation - Viral RNA Stabilization in Whole Blood

Magbio Blood STASIS™ DNA/RNA  Blood Collection Tubes

Blood STASIS™ DNA/RNA Blood Collection Tubes by MagBio Genomics are pre-filled evacuated tubes with a guanidine-free stabilizer that preserves both genomic DNA and RNA for up to 3 days at 4°C–37°C — enabling ambient-temperature blood transport for NGS, RT-qPCR, and cancer research. Available in 3 mL, 6 mL, and 9 mL.

Features

Sample

Collection Volume

Storage and Transport temperature

Shelf-Life Stability

Sample Stability

Applications

Blood STASIS™ DNA/RNA  ANY SIZE (3 Tubes)

Blood STASIS™ DNA/RNA 3 mL (200)

Blood STASIS™ DNA/RNA 6 mL (100)

Blood STASIS™ DNA/RNA 9 mL (100)

Stabilization Reagents

<h2>What are Stabilization Reagents?</h2>
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Stabilization reagents are aqueous solutions added to biological samples&mdash;tissue, blood, saliva, swabs, feces, or environmental specimens&mdash;immediately after collection to inhibit nuclease activity, inactivate infectious agents, and preserve nucleic acid integrity during storage and transport at ambient temperature. They replace immediate snap-freezing in workflows where cold-chain logistics are impractical or unavailable. Choose stabilization reagents when samples must be transported at room temperature, stored before processing, or collected in remote or field settings where freezing is impossible.
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<h2>What you will find:</h2>
&nbsp;
<ul>
<li>DNA stabilization reagents for genomic DNA preservation</li>
<li>RNA stabilization reagents for transcriptomics and gene expression studies</li>
<li>Dual DNA/RNA stabilization buffers for broad molecular workflows</li>
<li>Blood stabilization solutions for clinical and diagnostic sampling</li>
<li>Tissue stabilization reagents for biopsy and solid sample preservation</li>
<li>Stool and microbiome stabilization solutions for sequencing studies</li>
<li>Pre-filled stabilization reagent tubes (1 mL&ndash;10 mL formats)</li>
</ul>
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<h2>How to Choose Stabilization Reagents</h2>
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Nucleic Acid Target (DNA, RNA, or Both)
DNA-stabilizing reagents preserve genomic and microbial DNA during storage and transport. RNA-stabilizing reagents must rapidly inactivate RNases to maintain RNA integrity for transcriptomics and gene expression studies. For workflows requiring both DNA and RNA, select reagents validated for dual preservation, and confirm they maintain suitable RNA integrity over your anticipated storage period.
Sample Matrix Compatibility
Reagent choice depends on sample type. Liquid blood, tissue, stool, saliva, and environmental samples each require appropriate stabilization protocols and reagent volumes recommended by the manufacturer. Using insufficient reagent volume or an incompatible stabilization protocol can reduce preservation efficiency.
Downstream Compatibility
Verify that the stabilization reagent is compatible with your intended nucleic acid extraction kit and downstream applications, including PCR, qPCR, NGS, or transcriptomic analysis. Some stabilization reagents can be processed directly with compatible extraction kits, while others require removal before extraction.
Infectious Agent Inactivation
For potentially infectious clinical or environmental samples, select stabilization reagents that have been validated to inactivate relevant pathogens while preserving nucleic acid quality. Confirm any regulatory clearances or pathogen-specific validation claims for the exact product being used.
Storage Duration
Select a stabilization reagent validated for your expected storage time and temperature. Some products support short-term ambient storage, while others are designed for extended preservation at room temperature, refrigerated, or frozen conditions. Always follow the manufacturer's validated storage recommendations.
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<h2>Specifications Context</h2>
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Stabilization reagents should be added immediately after sample collection because delayed stabilization can reduce RNA integrity, particularly in tissue samples. Products are available in multiple formulations and container sizes for laboratory and field use. Always verify the recommended reagent concentration, sample-to-reagent ratio, storage conditions, and compatibility with your downstream workflow according to the manufacturer's documentation.
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MBP can help align the stabilization system with your exact workflow.&nbsp;<a href="https://mbpinc.net/contact-us">Contact the MBP team</a> for bulk pricing and PO ordering.

Magbio CTL Medium

MagBio CTL Medium™ by MagBio Genomics is a guanidine-free stabilization buffer that lyses and inactivates viral, bacterial, and fungal pathogens in swab and urine samples at room temperature. DNA remains stable for 45 days and RNA for 8 days at ambient temperature; compatible with KingFisher™ Flex automation using MAG-S2 beads. Available in 500 mL and 1,000 mL formats.