Automated Purification Systems

Automated Purification Systems Accessories

<h2>What Are Automated Purification System Accessories?</h2>
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Automated purification system accessories include consumables and support components used with automated nucleic acid purification platforms. Common accessories include tip combs, magnetic tip combs, deep-well plates, elution plates, reagent vessels, sample racks, and system control devices. These components support sample preparation, reagent handling, magnetic bead-based purification workflows, and routine instrument operation. Choose Automated Purification System Accessories to support efficient magnetic bead-based purification, minimize workflow interruptions, and maintain reproducible results.
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<h2>What You Will Find:</h2>
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<ul data-start="25" data-end="537" data-is-last-node="" data-is-only-node="">
<li data-section-id="q24m79" data-start="25" data-end="130">Tip combs and magnetic tip combs for automated magnetic bead-based nucleic acid purification workflows.</li>
<li data-section-id="5lldu5" data-start="131" data-end="229">Deep-well and elution plates designed for sample processing, washing, and nucleic acid recovery.</li>
<li data-section-id="by507b" data-start="230" data-end="325">Reagent vessels for automated handling of buffers, wash solutions, and purification reagents.</li>
<li data-section-id="u7msh5" data-start="326" data-end="420">Sample racks and support components for organized workflow setup and consumable positioning.</li>
<li data-section-id="dj84rx" data-start="421" data-end="537" data-is-last-node="">Platform-specific accessories and control devices that support routine operation of IsoPure&trade; purification systems.</li>
</ul>
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<h2>How to Choose Accessories for Automated Purification Systems</h2>
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Tip combs and magnetic tip combs
Tip combs and magnetic tip combs are used during automated magnetic bead handling and nucleic acid purification workflows. Select accessories designed for the specific purification platform to ensure proper fit, alignment, and operation.
Deep-well and elution plates
Deep-well plates are used for sample processing and reagent handling, while elution plates are used to collect purified nucleic acids following extraction. Confirm plate format and compatibility with the instrument and workflow requirements before ordering.
Reagent vessels and sample racks
Reagent vessels hold buffers, wash solutions, and other workflow reagents required during automated purification procedures. Sample racks provide organized positioning of vessels and consumables to support efficient workflow setup and operation.
System accessories
Additional accessories, including preconfigured control tablets and demonstration kits, support instrument operation, training, workflow development, and system setup activities.
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<h2>Specifications Context</h2>
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Automated purification workflows depend on the correct combination of consumables and instrument accessories. Tip combs, plates, reagent vessels, and racks should be selected according to the instrument model and workflow format to ensure reliable sample handling and purification performance. Routine replacement of consumable components helps maintain workflow consistency and minimizes the risk of cross-contamination.
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To discuss product availability or receive guidance on accessory selection, <a href="https://mbpinc.net/contact-us">contact the MBP team.</a>

Automated Purification System Accessories

6-well reagent vessel for IsoPure Mini, cs 100

AP1016-6W by Accuris is a case of 100 sterile virgin polypropylene 6-well reagent strips for the IsoPure™ Mini Automated Magnetic Bead Purification System (AP1016). Each strip accommodates up to 8 samples per run, reducing reagent waste compared to a full 96-well plate when batch sizes are small. Strips fit the IsoPure Mini's aluminum heating rack for lysis and elution thermal steps.

Manufectuer

8-place magnetic tip comb for IsoPure Mini, cs 50

AP1016-MC by Accuris Instruments is a case of 50 eight-place magnetic tip combs for the IsoPure Mini automated purification system (AP1016). Used to pellet magnetic beads during DNA, RNA, and protein purification cycles, enabling clean supernatant removal across all 8 sample positions simultaneously.

96 deep well plates for IsoPure™, cs 50

AP1096-DWP by Accuris Instruments is a case of 50 sterile, polypropylene 96-well deep well plates designed as the certified consumable for the IsoPure™ 96 automated magnetic bead purification system (AP1096). Plates are contaminant-free and dimensionally matched to the IsoPure 96 instrument deck for reproducible nucleic acid extraction yields across high-throughput sample batches.

96 well elution plates for IsoPure™, cs 100

AP1096-ELP by Benchmark Scientific are 96-well polypropylene elution plates supplied in a case of 100, designed exclusively for the IsoPure™ 96 automated magnetic bead purification system (AP1096 / AP1096-E). Each plate collects purified DNA or RNA eluate from all 96 samples simultaneously.

<h2>What Are Automated Purification Systems?</h2>
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Automated purification systems are integrated chromatography instruments that combine a multi-channel solvent delivery pump, a sample injection module, a chromatography column holder (accepting prepacked cartridges or reusable columns), a UV/Vis (and optionally ELSD or mass detector) detection system, and an automated fraction collector into a single controlled platform. The system runs gradient elution programs that change solvent composition over time, separating sample components by their differential affinity for the stationary phase. UV signal peaks trigger fraction collection into numbered tubes or microplates, eliminating the need for the operator to monitor the separation and manually collect fractions. Mass-directed systems add an inline mass spectrometer to trigger fraction collection on a specific molecular mass rather than UV absorbance, enabling selective collection of the target compound even when it co-elutes with impurities of similar UV absorption. Specify an automated purification system when your lab runs more than 3 to 5 flash chromatography purifications per day; the time saved on each run compounds rapidly and improves fraction quality through consistent, reproducible gradient programming.
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<h2 dir="ltr">What You Will Find:</h2>
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<ul>
<li data-section-id="1xaq5zs" data-start="25" data-end="248">Compact and high-throughput magnetic bead-based instruments, including IsoPure&trade; Mini, IsoPure&trade; 24, IsoPure&trade; 96, and Nucleic Acid Purifier 16 systems for automated nucleic acid purification.</li>
<li data-section-id="124t8zs" data-start="249" data-end="383">Compatible 24-well and 96-well deep-well plates and elution plates for automated purification workflows.</li>
<li data-section-id="ucx4qa" data-start="384" data-end="516">Replacement magnetic tip combs for IsoPure&trade; Mini, IsoPure&trade; 24, and IsoPure&trade; 96 automated purification systems.</li>
<li data-section-id="15pcqjt" data-start="517" data-end="657">Reagent vessels and aluminum sample racks designed for efficient sample loading and workflow organization.</li>
<li data-section-id="4rzy3m" data-start="658" data-end="817" data-is-last-node=""><a href="https://mbpinc.net/equipments/purification-and-separation-equipment/automated-purification-systems/automated-purification-system-accessories">System Accessories</a>, including Tablets, demo cases, and other compatible accessories to support the setup, operation, and maintenance of automated purification systems.</li>
</ul>
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<h2>How to Choose an Automated Purification System</h2>
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Flash chromatography vs. preparative HPLC
Automated flash chromatography systems (operating at 5 to 30 bar with spherical 25 to 100 micron silica or C18 cartridges) are optimized for fast, cost-effective purification of 0.1 to 10 g samples with throughputs of 3 to 10 runs per day. Preparative HPLC systems (operating at 50 to 300 bar with 5 to 25 micron particle columns) provide higher resolution for complex mixtures, smaller sample loads (mg to g scale), and are required when flash chromatography cannot resolve closely similar compounds. Some systems integrate both flash and prep HPLC capability in one instrument.
Sample load and column capacity
Match the column loading to your typical sample mass. Standard flash cartridges in 4 g, 12 g, 25 g, 40 g, 80 g, and 120 g silica sizes handle sample loads of roughly 0.04 to 1.2 g on normal-phase silica. Reversed-phase C18 cartridges handle lower loads per gram of silica. For larger sample loads (5 to 100 g), large-diameter columns or multi-injection protocols are used. Confirm the system's maximum column size and flow rate capacity against your typical sample mass.
Detection: UV/Vis vs. ELSD vs. mass directed
UV/Vis detection (monitoring at 254 nm and 280 nm) is standard and sufficient for compounds with a chromophore (most synthetic products). Evaporative light scattering detection (ELSD) is added for compounds with poor UV absorption (lipids, carbohydrates, alkyl chains). Mass-directed purification adds an inline single-quadrupole mass spectrometer that triggers fraction collection only when the target mass is detected; this is the highest-selectivity option for purifying one compound from a complex mixture, but at significantly higher instrument cost.
Number of solvent lines
Entry-level systems use two solvent lines (binary gradient). Advanced systems provide four solvent lines (quaternary gradient), enabling more complex separation strategies, modifier additions (e.g., acetic acid or ammonium formate in reversed-phase), and reduced operator setup time for multi-method labs. For most flash chromatography in synthetic chemistry, a binary gradient (organic/non-polar + polar modifier) is sufficient.
Software and workflow integration
Automated systems vary widely in software capability: basic systems provide gradient programming and peak detection; advanced platforms add automatic injection, queue management for multiple samples, solvent level monitoring, LIMS connectivity, and 21 CFR Part 11 compliance for regulated pharmaceutical environments. For open-access use in multi-chemist departments, queue-based software allowing each user to submit samples independently increases throughput.
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<h2>Specifications Context</h2>
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Column and cartridge consumables are a significant ongoing cost for automated purification systems; prepacked silica cartridges for flash systems are single-use or limited-use. Confirm cartridge availability and pricing for the specific system before purchase, as some systems lock users to proprietary cartridges at premium pricing while others accept standard-thread cartridges from multiple suppliers. Solvent consumption (L/run) scales with column size and flow rate; larger cartridges and longer gradients use more solvent. For high-throughput labs, solvent waste management (evaporation, recycling, or disposal) is a practical operational consideration. UV detection wavelength settings (254 nm for aromatic compounds, 210 to 220 nm for carbonyl-containing compounds) should be confirmed for your compound class to avoid missing low-UV-absorbing peaks.&nbsp;
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Complete your purification setup today&mdash;browse our accessories collection and <a href="https://mbpinc.net/contact-us">contact the MBP team</a> for a quote.

Accuris IsoPure Automated Purification Systems

User Manual

Typical Purification Process

IsoPure™ Mini, Automated Extraction Instrument

6-well sample strips for IsoPure Mini, pack of 100

8-place magnetic tip comb for IsoPure Mini, pack of 50

Android Tablet preloaded with IsoPure App

AP1024 by Accuris Instruments is the IsoPure™ 24, an automated magnetic bead-based nucleic acid purification system for up to 24 samples per run in deep-well plate format. The 8-position touchscreen-controlled carousel automates all purification steps — mixing, magnetic transfer, washing, and elution — in as little as 10 minutes. Compatible with KingFisher-format combs, 24-well deep-well plates, and all popular magnetic bead kits.

IsoPure™ 24, Automated Purification System, 115V

IsoPure™ 24, Automated Purification System, 230V

Aluminum Sample Rack for AP1016-6W reagent vessels

AP1016-ASR by Benchmark Scientific (Accuris Instruments) is an aluminum sample rack for holding AP1016-6W six-well reagent vessels during IsoPure Mini (AP1016/AP1016-E) automated magnetic bead purification runs. Aluminum construction, 7.0&nbsp;lbs, stabilizes reagent vessels for reproducible bead-based DNA, RNA, and protein purification workflows.

IsoPURE Mini Demo Case

Capacity/sample volume

Magnetic bead recovery

Lysis temperature range

Elution temperature range

Mixing Speed

Programming Control

Program Memory

Communication Ports

Internal Lighting

Contamination Control

Scanner

Dimensions

Weight

Electrical Input

Warranty

IsoPURE™ 24 14.6mL Deep Well Plate, 24/pack

AP1024-DWP by Accuris Instruments is a pack of 24 sterile polypropylene 14.6 mL deep well plates, the certified consumable for the IsoPure™ 24 automated magnetic bead purification system (AP1024). The 14.6 mL per-well capacity provides the headroom needed for multi-step bead wash cycles in 24-sample parallel nucleic acid extraction runs.

IsoPURE™ 24 Tip Combs, 24/pack

AP1024-TC by Benchmark Scientific are 24-place tip combs (24/pack) for the IsoPure™ 24 automated magnetic bead purification system and compatible KingFisher Flex / Duo Prime platforms. Single-use per run; each pack provides 24 full extraction runs.

IsoPure™ 96, Automated Purification System

AP1096 by Accuris Instruments is the IsoPure™ 96, a fully automated magnetic bead-based nucleic acid purification system processing 96 samples per run in 10–60 minutes. It handles sample volumes from 50 µL to 1,000 µL, reaches lysis and elution temperatures up to 120°C, and stores up to 100 protocols on a 7.0-inch color touchscreen. Built-in 3 W UVC decontamination, >95% bead recovery, and universal 120–240 VAC input. Compatible with all popular magnetic bead purification kits.

Capacity / sample volume

Display

Plate positions

Mixing speed

Programming control

Program memory

Communication ports

Magnetic bead recovery rate

Contamination control

Electrical input

IsoPure™ 96, Automated Purification System, 115V

IsoPure™ 96, Automated Purification System, 230V

IsoPure™ Mini - Automated Extraction Instrument Overview

IsoPure™ Mini, Automated Purification System

The AP1016 IsoPure™ Mini by Accuris Instruments is an automated magnetic bead-based purification system processing up to 16 samples (50–1,000 µL) in 10–60 minutes, with a 37°C–120°C temperature block, &gt;95% bead recovery, built-in 3W UVC lamp, 100-protocol memory, and PC/Android programmability — at a footprint of 7.9 × 10.2 × 11.8 inches.

IsoPure™ Mini, Automated Purification System, 115V

IsoPure™ Mini, Automated Purification System, 230V

Tip Comb for IsoPure™ 96, cs 50

AP1096-TC by Accuris Instruments is a case of 50 tip combs designed for the IsoPure™ 96 Automated Purification System (AP1096). Each tip comb fits the AP1096's 96-position carousel and transfers magnetic beads through wash and elution steps in automated nucleic acid purification runs. Single-use per run; 50 combs per case for sustained high-throughput operation.