Name: DNA/RNA Shield SafeCollect Saliva Collection Kit
SKU: R1211
Availability: InStock

<h2 dir="ltr">What is DNA/RNA Shield?</h2>
 DNA/RNA Shield is a nucleic acid stabilization reagent developed by Zymo Research that preserves DNA and RNA in biological samples at ambient temperature (15&ndash;25 &deg;C) without freezing or refrigeration. The aqueous reagent permeates cells on contact, inactivating nucleases and infectious agents&mdash;including viruses, bacteria, fungi, and parasites&mdash;while maintaining the genetic integrity and gene expression profiles of samples for up to 28 days at room temperature or multiple years at &minus;20 &deg;C. Sample types include cells, tissues, swabs, blood, saliva, urine, feces, plant material, insects, and environmental specimens. DNA/RNA Shield is the primary reagent for any workflow requiring ambient-temperature nucleic acid preservation from collection through extraction.
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<h2 dir="ltr">What you will find:</h2>
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DNA/RNA stabilization solution for biological sample preservation
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Ambient temperature sample preservation reagents
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1X and 2X concentration formats for different sample types
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Nucleic acid protection reagents for molecular workflows
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Pathogen-inactivating preservation solutions for safer handling
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Compatible solutions for PCR, qPCR, and sequencing workflows
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General-purpose nucleic acid preservation reagents for research use
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<h2 dir="ltr"> How to Choose the Right DNA/RNA Shield Format</h2>
 1&times; Solution vs. 2&times; Concentrate The 1&times; ready-to-use solution (catalog R1100) is used directly: add 1 volume of reagent per 1 volume of liquid sample, or submerge tissue fully. The 2&times; concentrate (R1200) is used to treat high-volume liquid samples (blood, urine) where diluting the sample would reduce nucleic acid input. Prepare a working 1&times; solution by mixing 2&times; concentrate 1:1 with the liquid sample at collection.
Pre-filled Devices vs. Bulk Reagent Pre-filled collection tubes, swab kits, lysis tubes, and saliva kits deliver accurate volumes at the point of collection without pipetting. Bulk reagent (50 mL&ndash;250 mL) is used in the laboratory for tissue immersion, custom plate-based workflows, or when preparing multiple collection devices at once.
DNA-Only vs. Dual DNA + RNA Preservation DNA/RNA Shield preserves both simultaneously. If only DNA is required (e.g., genotyping, RFLP), any stabilization reagent is adequate. When RNA is the target&mdash;particularly for transcriptomics, gene expression, or viral RNA detection&mdash;DNA/RNA Shield is preferred over RNAlater because it requires no removal before extraction and prevents freeze-thaw degradation.
Downstream Extraction Compatibility DNA/RNA Shield is directly compatible with Zymo Research Quick-DNA, Quick-RNA, ZymoBIOMICS, and Direct-zol kits without removal. Third-party kits (QIAGEN DNeasy, Thermo Fisher MagMAX) require pilot testing; residual shield reagent can cause inhibition in some column-based systems at high concentrations.
Volume Per Sample For swab samples: pre-filled 1 mL or 2 mL collection tubes. For tissue: 10&times; volume reagent per gram; a 50 mg biopsy needs ~500 &micro;L reagent in a 2 mL tube. For stool: 1 mL reagent per 50&ndash;100 mg sample. For whole blood: use the 2&times; concentrate at a 1:5 blood-to-reagent ratio for DNA/RNA blood collection tubes.
<h2 dir="ltr"> Specifications Context</h2>
 DNA/RNA Shield has received FDA 510(k) clearance (K202641) for SARS-CoV-2 RNA preservation and viral inactivation. The reagent is supplied as a clear aqueous solution, RNase-free, DNase-free, and PCR-inhibitor-free per lot certificate. At &minus;20 &deg;C storage, DNA stability extends to 2+ years with no measurable freeze-thaw degradation. A precipitate may form at temperatures below 15 &deg;C; resolving requires warming to &gt;37 &deg;C for 10 minutes; reagent function is unaffected. DNA/RNA Shield is among the most-cited sample stabilization reagents in published microbiome, environmental genomics, and infectious disease surveillance literature.
 MBP is a registered vendor for Howard Hughes Medical Institute, Vanderbilt University, and MD Anderson Cancer Center. Bulk volume and PO orders accepted. <a href="https://mbpinc.net/contact-us">Contact the MBP team&nbsp;</a>to request a quote.

DNA/RNA Shield

<h2 dir="ltr">What are Saliva Collection Devices?</h2>
 Saliva collection kits are non-invasive, all-in-one systems for collecting 1&ndash;2 mL of human saliva and immediately stabilizing the nucleic acid content&mdash;DNA, RNA, or both&mdash;using a pre-filled preservative reagent in a leak-proof polypropylene tube. They are used in genetic ancestry testing, population genomics, microbiome profiling, SARS-CoV-2 and respiratory virus detection, liquid biopsy research, and at-home or remote sampling studies. Collection requires only a spitting action with no phlebotomy or trained personnel. Choose saliva collection kits over blood-based collection when non-invasive sampling, self-collection, or at-home workflows are required. 
<h2 dir="ltr">What you will find:</h2>
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<li dir="ltr" role="presentation">Saliva collection kits with funnel-based sampling systems</li>
<li dir="ltr" role="presentation">DNA/RNA stabilization saliva tubes for molecular testing</li>
<li dir="ltr" role="presentation">Preservative-based saliva collection systems for ambient storage</li>
<li dir="ltr" role="presentation">Pathogen-inactivating saliva tubes for safer handling</li>
<li dir="ltr" role="presentation">Sterile saliva collection containers for clinical use</li>
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<h2> How to Choose Saliva Collection Devices</h2>
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 Nucleic Acid Target DNA-stabilizing saliva kits (e.g., Zymo DNA/RNA Shield saliva format) preserve genomic DNA for genotyping, GWAS, and ancestry applications. Dual DNA/RNA kits preserve both intracellular and extracellular nucleic acids, enabling RNA-seq and liquid biopsy alongside genotyping from a single specimen&mdash;an advantage over single-analyte formats.
 Preservative Chemistry Zymo Research saliva collection kits use 2 mL of DNA/RNA Shield as the preservative, added post-collection via ampoule. This stabilizes DNA and RNA at ambient temperature for up to 28 days and inactivates viruses including SARS-CoV-2 for safe mailing. PAXgene Saliva Collector (Qiagen) uses a different chemistry that stabilizes DNA for up to 5 days at 4&ndash;25 &deg;C; check storage window before selecting for remote-collection studies with long transit times.
 Collection Volume Standard saliva collection tubes require 1.0&ndash;2.0 mL of spit. Reduced-volume devices (sponge or swab-based) are available for donors unable to produce adequate spit volume (pediatric, elderly). Confirm your extraction kit's minimum input volume against the expected collection yield.
 Leak-Proof and Shipping Compliance For mail-in studies, tubes must meet 95 kPa pressure test requirements for transport under IATA P650 and UN3373 Biological Substance Category B. Zymo Research and DNA Genotek saliva kits are validated for standard courier mailing; verify this specification before deploying at-home collection in clinical or population studies.
 Barcoding and Tracking High-throughput population studies benefit from tubes pre-labeled with unique serial numbers for secure, anonymous sample tracking. Select kit formats with barcoded tubes when managing hundreds to thousands of samples across multi-site research.
<h2 dir="ltr"> Specifications Context</h2>
 Saliva collection tubes are manufactured from medical-grade polypropylene (PP) and are validated as leak-proof to 95 kPa for mailing compliance. The collection funnel attaches to the tube body; after saliva collection, the funnel is removed, and the preservative ampoule is emptied into the tube, bringing the preservative: saliva ratio to approximately 1:1. Zymo Research saliva kits yield 5&ndash;20 &micro;g genomic DNA and 1&ndash;10 &micro;g total RNA from a standard 2 mL saliva sample after extraction with Quick-DNA/RNA kits. Saliva-based nucleic acid collection is validated for SARS-CoV-2 RNA detection, human microbiome profiling, and whole-genome sequencing (WGS) workflows. 
MBP is a registered vendor for leading research institutions, including the Howard Hughes Medical Institute and the MD Anderson Cancer Center. <a href="https://mbpinc.net/contact-us" style="color: #236fa1; text-decoration: underline;">Contact the MBP team</a> for bulk pricing or PO-based ordering.

Saliva Collection

MSDS

Protocol

R1211-Protocol

DNA/RNA Shield SafeCollect Saliva Collection Kit

DNA/RNA Shield SafeCollect Saliva Collection Kit by Zymo Research collects up to 2 mL of saliva or sputum and immediately stabilizes nucleic acids with built-in 2X DNA/RNA Shield — no cold chain needed. DNA remains stable at ambient temperature for more than 2 years; RNA for more than 1 month. Available in single, 10-pack, and 50-pack formats for biobanking and remote collection programs, plus a DX (CE-marked) version of the single kit (R1211-E).