Name: DNA/RNA Shield™ Fecal Collection Tubes
SKU: R1101
Availability: InStock

<h2 dir="ltr">What are Fecal Collection Tubes?</h2>
 Fecal collection tubes are pre-filled, single-use containers for stabilizing DNA, RNA, and the microbial community profile of stool specimens at ambient temperature&mdash;eliminating the need for immediate freezing after collection. A spoon or spatula attached to the screw cap enables hygienic self-collection of approximately 200&ndash;500 mg of stool directly into the preservative. Tubes are used in gut microbiome research (16S rRNA, metagenomics, metatranscriptomics), intestinal pathogen surveillance, SARS-CoV-2 wastewater and fecal RNA detection, and colorectal disease biomarker studies. Choose fecal collection tubes with an RNA-stabilizing preservative (DNA/RNA Shield) when both DNA and RNA targets&mdash;or fragile viral RNA&mdash;must be preserved from stool specimens shipped at room temperature.
&nbsp;
<h2 dir="ltr">What you will find:</h2>
&nbsp;
<ul>
<li dir="ltr" role="presentation">Fecal collection tubes with stabilization preservatives for DNA/RNA preservation</li>
<li dir="ltr" role="presentation">Stool sample collection kits with integrated sampling spoons or swabs</li>
<li dir="ltr" role="presentation">Microbiome preservation tubes for sequencing and research applications</li>
<li dir="ltr" role="presentation">Sterile fecal collection containers for clinical diagnostics</li>
<li dir="ltr" role="presentation">Leak-proof transport tubes for safe sample handling</li>
<li dir="ltr" role="presentation">Pathogen-inactivating collection systems for improved biosafety</li>
</ul>
<h2 dir="ltr"> How to Choose Fecal Collection Tubes</h2>
 Preservative Chemistry Zymo Research DNA/RNA Shield fecal tubes (catalog R1101, 9 mL fill) stabilize DNA and RNA and take a microbial snapshot at the time of collection by inactivating viruses and pathogens. Standard OMNIgene&bull;GUT (DNA Genotek) tubes stabilize DNA for microbiome DNA profiling, but are not validated for RNA preservation. For any RNA target&mdash;metatranscriptomics, viral RNA, host gene expression in stool&mdash;choose DNA/RNA Shield-based tubes.
Bead Format vs. No Beads Catalog R1101 is a 9 mL tube without beads for direct stool input, followed by vortexing. Catalog R1137 (4 mL, with 5 glass beads) facilitates mechanical homogenization of hard fecal pellets, particularly from mouse and non-human primate models. Choose the bead format when working with solid or compacted stool material requiring physical disruption before stabilization.
Tube Volume and Sample Input Standard Zymo fecal tubes accommodate 200&ndash;500 mg of stool in 9 mL of reagent or 100&ndash;200 mg in 4 mL (bead format). Confirm fill volume against your extraction kit's minimum input. Over-filling exceeds the validated preservative-to-sample ratio and risks incomplete pathogen inactivation and nucleic acid degradation.
Downstream Application Compatibility All DNA/RNA Shield fecal tubes are compatible with Zymo ZymoBIOMICS DNA Miniprep, Quick-RNA, and Direct-zol kits without reagent removal. For third-party kits (QIAGEN PowerSoil, Thermo Fisher MagMAX), run a pilot test: residual Shield at high concentration may cause column inhibition in some bead-based soil kits.
Kit vs. Tube-Only Format The Zymo Individual Fecal Collection Kit (R1101-K) packages one fecal tube, a Feces Catcher, gloves, and a biohazard bag in a sealed pouch&mdash;suitable for mailed at-home collection in population studies. The tube-only format (10-pack or 50-pack) suits high-throughput lab processing where accessories are managed separately.
<h2 dir="ltr"> Specifications Context</h2>
 Zymo Research DNA/RNA Shield fecal tubes are 20 &times; 76 mm screw-cap polypropylene vessels with a spoon integrated into the cap. The reagent preserves nucleic acids for 28 days at ambient temperature (15&ndash;25 &deg;C); samples can be frozen at &minus;20 &deg;C or &minus;80 &deg;C for long-term archival. SARS-CoV-2 RNA preservation in fecal samples using DNA/RNA Shield was evaluated in a 2021 Nature Communications study (Huber et al.) that benchmarked it against OMNIgene&bull;GUT and unpreserved PBS controls, demonstrating superior viral RNA recovery after ambient-temperature storage. Fecal samples stabilized with DNA/RNA Shield are non-infectious and compatible with standard courier shipping under UN3373 and IATA P650. As of 2026, the ZR1101 and ZR1137 catalog numbers are available through MBP with direct PO ordering. 
&nbsp;
The <a href="https://mbpinc.net/contact-us" style="color: #236fa1; text-decoration: underline;">MBP team</a> can help match the right fecal collection solution to your laboratory workflow.

Fecal Collection

<h2 dir="ltr">What is DNA/RNA Shield?</h2>
 DNA/RNA Shield is a nucleic acid stabilization reagent developed by Zymo Research that preserves DNA and RNA in biological samples at ambient temperature (15&ndash;25 &deg;C) without freezing or refrigeration. The aqueous reagent permeates cells on contact, inactivating nucleases and infectious agents&mdash;including viruses, bacteria, fungi, and parasites&mdash;while maintaining the genetic integrity and gene expression profiles of samples for up to 28 days at room temperature or multiple years at &minus;20 &deg;C. Sample types include cells, tissues, swabs, blood, saliva, urine, feces, plant material, insects, and environmental specimens. DNA/RNA Shield is the primary reagent for any workflow requiring ambient-temperature nucleic acid preservation from collection through extraction.
&nbsp;
<h2 dir="ltr">What you will find:</h2>
&nbsp;
<ul>
<li dir="ltr" aria-level="1">
DNA/RNA stabilization solution for biological sample preservation
</li>
<li dir="ltr" aria-level="1">
Ambient temperature sample preservation reagents
</li>
<li dir="ltr" aria-level="1">
1X and 2X concentration formats for different sample types
</li>
<li dir="ltr" aria-level="1">
Nucleic acid protection reagents for molecular workflows
</li>
<li dir="ltr" aria-level="1">
Pathogen-inactivating preservation solutions for safer handling
</li>
<li dir="ltr" aria-level="1">
Compatible solutions for PCR, qPCR, and sequencing workflows
</li>
<li dir="ltr" aria-level="1">
General-purpose nucleic acid preservation reagents for research use
</li>
</ul>
<h2 dir="ltr"> How to Choose the Right DNA/RNA Shield Format</h2>
 1&times; Solution vs. 2&times; Concentrate The 1&times; ready-to-use solution (catalog R1100) is used directly: add 1 volume of reagent per 1 volume of liquid sample, or submerge tissue fully. The 2&times; concentrate (R1200) is used to treat high-volume liquid samples (blood, urine) where diluting the sample would reduce nucleic acid input. Prepare a working 1&times; solution by mixing 2&times; concentrate 1:1 with the liquid sample at collection.
Pre-filled Devices vs. Bulk Reagent Pre-filled collection tubes, swab kits, lysis tubes, and saliva kits deliver accurate volumes at the point of collection without pipetting. Bulk reagent (50 mL&ndash;250 mL) is used in the laboratory for tissue immersion, custom plate-based workflows, or when preparing multiple collection devices at once.
DNA-Only vs. Dual DNA + RNA Preservation DNA/RNA Shield preserves both simultaneously. If only DNA is required (e.g., genotyping, RFLP), any stabilization reagent is adequate. When RNA is the target&mdash;particularly for transcriptomics, gene expression, or viral RNA detection&mdash;DNA/RNA Shield is preferred over RNAlater because it requires no removal before extraction and prevents freeze-thaw degradation.
Downstream Extraction Compatibility DNA/RNA Shield is directly compatible with Zymo Research Quick-DNA, Quick-RNA, ZymoBIOMICS, and Direct-zol kits without removal. Third-party kits (QIAGEN DNeasy, Thermo Fisher MagMAX) require pilot testing; residual shield reagent can cause inhibition in some column-based systems at high concentrations.
Volume Per Sample For swab samples: pre-filled 1 mL or 2 mL collection tubes. For tissue: 10&times; volume reagent per gram; a 50 mg biopsy needs ~500 &micro;L reagent in a 2 mL tube. For stool: 1 mL reagent per 50&ndash;100 mg sample. For whole blood: use the 2&times; concentrate at a 1:5 blood-to-reagent ratio for DNA/RNA blood collection tubes.
<h2 dir="ltr"> Specifications Context</h2>
 DNA/RNA Shield has received FDA 510(k) clearance (K202641) for SARS-CoV-2 RNA preservation and viral inactivation. The reagent is supplied as a clear aqueous solution, RNase-free, DNase-free, and PCR-inhibitor-free per lot certificate. At &minus;20 &deg;C storage, DNA stability extends to 2+ years with no measurable freeze-thaw degradation. A precipitate may form at temperatures below 15 &deg;C; resolving requires warming to &gt;37 &deg;C for 10 minutes; reagent function is unaffected. DNA/RNA Shield is among the most-cited sample stabilization reagents in published microbiome, environmental genomics, and infectious disease surveillance literature.
 MBP is a registered vendor for Howard Hughes Medical Institute, Vanderbilt University, and MD Anderson Cancer Center. Bulk volume and PO orders accepted. <a href="https://mbpinc.net/contact-us">Contact the MBP team&nbsp;</a>to request a quote.

DNA/RNA Shield

MSDS

Protocol

DNA/RNA Shield™ Fecal Collection Tubes

R1101 by Zymo Research is the DNA/RNA Shield&trade; Fecal Collection Tube, a 10-pack of 20 &times; 76 mm screw-cap tubes pre-filled with 9 mL of DNA/RNA Shield. Each tube includes an integrated collection spoon in the cap. At a 1 g sample input, DNA remains stable for at least 2 years at ambient temperature (4&ndash;25&deg;C) and RNA for at least 1 month, with indefinite stability at &le;&minus;20&deg;C. Pathogens are inactivated at point of collection, enabling safe ambient transport. Also available as a CE-marked version (R1101-E) or with 5 glass beads for in-tube homogenization (R1137).
Compatible with the R1101-1-10 Feces Catcher for hands-free at-home collection. Pair with downstream Zymo extraction kits for microbiome, metagenomics, and qPCR workflows.
MBP is a registered vendor for Howard Hughes Medical Institute, Vanderbilt University, MD Anderson Cancer Center, Eurofins, and many other institutes across the USA. Order via <a href="https://www.mbpinc.net/quickorder">Quick Order</a> or contact <a href="mailto:customerservice@mbpinc.net">customerservice@mbpinc.net</a>.