Anti-Shc1 (Phospho-Tyr427)

Y011317 by MBP is a rabbit polyclonal antibody detecting Shc1 (SHC1) phosphorylated at Tyr427 in the p66Shc isoform (equivalent to Tyr317 in p52Shc), the CH1-domain Grb2 docking site phosphorylated by activated RTKs (EGFR, InsR, TrkA/B) that couples receptor activation to Ras–MAPK and PI3K–AKT signalling. MW: p66 ~66 kDa, p52 ~52 kDa, p46 ~46 kDa. WB, IHC, IF. Human, mouse, rat. Research Use Only.