Anti-c-Kit (Phospho-Tyr721)

Y011240 by MBP is a rabbit polyclonal antibody detecting c-Kit (KIT/CD117) phosphorylated at Tyrosine 721, the SCF-induced autophosphorylation site in the kinase insert domain that docks the PI3K p85 subunit to activate PI3K–AKT signalling. Constitutively active in KIT-mutant GIST and mastocytosis. MW ~145 kDa (glycosylated). WB, IHC, IF; human. Research Use Only.