How To Select Well Microplates For Biological Screening

If you are looking to find out about microplates, you came to the right place. 

This blog entails everything related to well microplates and their use in biological screening. All the key factors of these plates have been discussed below. 

To process a greater number of samples simultaneously for Biological screening, the use of multi-well microplates is significant. The plates ensure to contain the samples discretely and safe from clustering. For carrying out different tests and diagnoses, it is necessary to select a suitable type of microplate. The right size, volume, colour, and surface of the plate need to be chosen accurately. All the elements of the plate make a big difference in the final results of the screening. 

What Are Microplates

According to the available history, microplates first came into use in 1950 in Hungary. The initial purpose of these plates was to do serological testing for the influenza virus. However, by that time, the use of microplates became more common. Nowadays, these plates have become one of the top essentials for screening and diagnosis. 

 

The design of the plate and the spiral loop contains the liquid in the compartments. The sections of the plate help the liquid to stay intact and free from combining. The development of these plates helps identify the risks of the virus, the use of drugs, and the potential of the disease. 

The points below provide an insight into well microplates.

• They are the most popular for biological screening.
• Their use is prevalent for biological measurements.
• They are suitable for numerous applications.
• They ease the technicians by providing a convenient way of liquid screening with discretion.

Importance Of Microplates:

The importance of microplates is crucial for many kinds of screening. They are the most significant factor in getting a favourable outcome. Almost every lab and screening facility has these plates. It makes the microplates one of the major components of conducting the biological screening. 

 

The microplates are common because of their compatibility with the screening instruments. They combine easily with every component without any inconvenience. The following properties of these plates determine their significance. 

 

• Suitable for different temperatures and have measurement stability.
• They are flat, which makes them more convenient.
• Compatible with chemicals and biological products.
• The surface has lower absorption of chemicals.
• Suitable with different optical detectors. 

 

Manufacturing Process Of Microplates:

Before using the well microplate, it is vital to understand their manufacturing process. It involves injecting a liquid polymer into the moulding object. The main polymer frame is fitted according to the size and volume of the plate. For obtaining a clear-bottom plate, the mould is injected with a pre-clear bottom film. The name of this process is overmolding. For colourful microplates, the manufacturers use pigments to colour the plates. 

 

It is necessary to ensure accuracy during the manufacturing process of the microplates. Sometimes, the process results in lower quality of the plates, thereby affecting the screening. That’s why it is imperative to make sure that the manufacturing process of microplates turns out properly. 

 

Selection Of Microplates:

The most significant task during the biological screening is the selection of a perfect microplate. The decisions made on the microplates reflect later in the results. Therefore, without enough knowledge of these plates, the selection of microplates can become complex. It is necessary to consider the factors like coating, temperature, compatibility and quality of the plate. 

 

Many vendors and biological product dealers provide 384 well Plates or more for screening purposes. It depends on the technicians and lab workers to get the desired microplates. The different sizes and volumes of these plates are readily available in the market.

 

The following elements of the microplate are necessary to overlook.

 

• Microplate well density.
• Colour
• Microplate well shape
• Microplate well volume
• Polymers
• Surfaces and treatments

 

All the elements above hold immense importance in the selection of an optimal microplate. It’ll help to find the quality product without any inconvenience.

To conclude, it is necessary to find a reliable dealer of microplates, i.e., Molecular Biology Products (MBP INC). We provide high-quality products to satisfy our customers. The online shopping feature helps the customers to get the needed products without much effort. Our team caters to the needs of the clients by providing them with top-class products. 

Citation:

Auld DS Ph.D., Coassin PA B.S., Coussens NP Ph.D., et al. (June 1st, 2020. NCBI: Microplate Selection and Recommended Practices in High-throughput Screening and Quantitative Biology. Retrieved August 4th, 2021 from https://www.ncbi.nlm.nih.gov/books/NBK558077/