Molecular Biology

Evolution of Molecular Biology

Molecular Biology

Back in 1865, Mendel determined the laws of heritability and turned biology into an exact science. Albeit, the scientific community didn’t realize immediately how important his discovery was. It was rediscovered around 1900 by Correns, DeVries, and Tschermak, and it came down as a relief for science in the crisis. Many biologists in the 20th century were tired of the descriptive nature of science.

Charles Darwin’s and Mendel’s Contributions

Charles Darwin’s theory of evolution, which had provided a first glimpse at the larger mechanisms at work in the living world. Many scientists have felt that it was time to move on from descriptive science to one that untangles functional relationships.

On the other hand, the annual ‘Cold Spring Harbor Symposia on Quantitative Biology’ was a clear reference to that desire. Mendel’s four basic laws, which are focused and targeted on genetics, are formulated from experimentation and revolutionized biology as they have provided biologists with the logical basis for quantifying observations and investigating cause-effect relationships.

Relating to observed effects of the events which are caused by them is one of mankind’s strong mental abilities. Understanding the relationship will allow us to remember the recurrent events and estimate their likelihood and reproducibility. It usually works really well if a cause and its effect are connected to a short chain of events. However, the challenge increases with complexity.

The living organisms in their natural environment are probably the most complex entities to study, and their causes and effects aren’t linked to a single linear chain of casualties but rather in larger multidimensional and interconnected meshworks.

For unraveling and understanding the meshworks, you need to study simple systems, as it is important for them. You will learn about the chains of near-casualties that are reproducible and how it is comparable with the ‘laws of nature’ in physics. The crucial ‘rules of nature’ like the ‘genetic code,’ ‘protein biosynthesis at ribosomes,’ or the ‘operon’ are prime examples of such chains.

This new understanding has come up with a new, fresh debate about the reductionist versus holistic approaches to biological research. It has an implication on the public view and acceptance of biology and its application in medicine and the economy.

Max Delbruck On Evolution Of Molecular Biology

The laws of genetics that were formulated by Mendel can be compared to the basic laws of thermodynamics. It has attracted many physicists to biological research. Well-known German physicist Max Delbruck has spent his earlier research career in the astronomy and quantum physics field. Later on, he moved to biology in the late 1930s to study the rules of inheritance with the simplest organisms that are available. For instance, the bacterial viruses (bacteriophages) and their hosts.

As the political situation started to get worse in Germany, he left for the California Institute of Technology, which is located in Pasadena, CA, USA. He and Emory L. Ellis came up with the standard methods for this field. The author of the paper that is present is no exception, and he was trained as a physicist during the middle of the last century. He switched to studying biophysics and biology.

Followed by Jean J Weigle, his thesis advisor, who has quit his position as the professor of experimental physics in Geneva, Switzerland, to join Max Delbrucks’ phage group in Caltech as a research fellow. Speaking of research, if you are thinking of getting PCR plates, then you can check MBP Inc. for that.

It is an interesting fact that you should note that at that time, chemistry and biochemistry were not ready to participate in this new emerging field, which was going to become molecular biology. Initially, the main understanding of chemistry was focused on other aspects. It included a new peak of the research field, and everybody was convinced enough that the future would belong to chemistry.

The crucial laws of mass action and thermodynamics were established, and they were connected with every chemist. The specificity of organic substances was pretty much explained by stoichiometry and the steric arrangement of atoms. All of this knowledge resulted in many other important discoveries and products. Fertilizers, pesticides, plastics, and explosives, to name a few. They have made a huge impact on society, agriculture, medicine, consumer products, and the military.

Chemistry was mainly focused on synthesizing new molecules; biological polymers, therefore, had very little chance of being recognized as the conservative carrier of genetic information. Understanding of the role of enzymes as a catalyst of chemical reactions which are enforced in this general belief and the catalog of identified. On the other hand, the characterized enzymes grew daily and gave rise to a euphoria comparable to that of the heyday of genomics.

One of the most important questions is how heritable information is stored in the cell and has always remained open. DNA wasn’t considered seriously: how could a hetero polymer of only four different monomers explain the high specificities of genes? Proteins, with their 20 different amino acids, seemed like an accurate and more suitable answer.

Moreover, the specific structure of proteins or DNA as a linear sequence of amino acids or nucleotides isn’t suspected yet, let alone elucidated. Some of the biologists were instilled with this bias. This has gone so far that they have sought all kinds of alternative explanations for the final results of these experiments. For instance, Oswald Avery’s research demonstrates the important role of DNA in the genetic alteration of bacteria.

The evolution of molecular biology has upped its pace, and the latest biological and technological advancements have changed the whole field. Many researchers and scientists have done their part and contribution to this field. Get your research done with the best lab equipment from MBP Inc. Whether you need a skirted PCR Plate or centrifuges, we’ve got it all for you in one place!

Related Posts

Leave a Reply

Your email address will not be published. Required fields are marked *