

DEPC (Diethylpyrocarbonate) by Molecular Depot is a diethylpyrocarbonate, known as DEPC, used to inactivate ribonucleases by modifying histidine and lysine residues. The reagent carboxyethylates the imidazole of histidine, which destroys the active site of a ribonuclease, and it then hydrolyses in water to ethanol and carbon dioxide so that nothing is left behind. It is used to inactivate ribonucleases in water, buffers and solutions for RNA work and in protein chemistry as a histidine-modifying reagent. Each unit contains 1 g. MBP supplies Molecular Depot research reagents to research labs in the United States, Canada and worldwide.