

5-Hydroxyindole-2-carboxylic Acid (Highly Pure) by Molecular Depot is a 5-hydroxyindole-2-carboxylic acid, a reagent used in the preparation of oxadiazole analogues as SH2 domain inhibitors of the tyrosine kinase ZAP-70. ZAP-70 carries two SH2 domains that bind the phosphorylated motifs of the T cell receptor, and blocking those domains rather than the catalytic site is an approach to inhibiting the kinase selectively. It is used as a building block in kinase inhibitor and heterocyclic synthesis and in medicinal chemistry research. Each unit contains 5 g. MBP supplies Molecular Depot research reagents to research labs in the United States, Canada and worldwide.