|Description||HN12 cells were developed from tumor cells of a human with metastatic head and neck squamous cell carcinoma (HNSCC). This cell line expressed a truncated form of the p53 protein responsible for prevention of tumor development. The HN12 cell line can be used for further investigation of therapeutic pathways for inducing apoptosis in HNSCC.|
|Species||Human (H. sapiens)|
|Applications||For Research Use Only|
|Population Doubling Time||24 – 36 hours|
|Donor Disease||Metastatic head and neck squamous cell carcinoma (HNSCC)|
|Cell Type||Tumor Cells|
|Unit quantity||1×106 cells / 1.0 ml|
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Hitora, T., Yamamoto, T., Akisue, T., Marui, T., Nakatani, T., Kawamoto, T., … & Kurosaka, M. (2005). Establishment and characterization of a KIT‐positive and stem cell factor‐producing cell line, KTHOS, derived from human osteosarcoma. Pathology international, 55(2), 41-47.
Britt, E. L., Raman, S., Leek, K., Sheehy, C. H., Kim, S. W., Harada, H. (2019). Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment. PLOS ONE, 14(7), e0219398. https://doi.org/10.1371/journal.pone.0219398